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Review
. 2014 Sep 8:5:997.
doi: 10.3389/fpsyg.2014.00997. eCollection 2014.

Orexin-A controls sympathetic activity and eating behavior

Giovanni Messina  1 , Carmine Dalia  1 , Domenico Tafuri  2 , Vincenzo Monda  1 , Filomena Palmieri  1 , Amelia Dato  1 , Angelo Russo  1 , Saverio De Blasio  1 , Antonietta Messina  1 , Vincenzo De Luca  3 , Sergio Chieffi  1 , Marcellino Monda  1
Affiliations
Review

Orexin-A controls sympathetic activity and eating behavior

Giovanni Messina et al. Front Psychol. .

Abstract

It is extremely important for the health to understand the regulatory mechanisms of energy expenditure. These regulatory mechanisms play a central role in the pathogenesis of body weight alteration. The hypothalamus integrates nutritional information derived from all peripheral organs. This region of the brain controls hormonal secretions and neural pathways of the brainstem. Orexin-A is a hypothalamic neuropeptide involved in the regulation of feeding behavior, sleep-wakefulness rhythm, and neuroendocrine homeostasis. This neuropeptide is involved in the control of the sympathetic activation, blood pressure, metabolic status, and blood glucose level. This minireview focuses on relationship between the sympathetic nervous system and orexin-A in the control of eating behavior and energy expenditure. The "thermoregulatory hypothesis" of food intake is analyzed, underlining the role played by orexin-A in the control of food intake related to body temperature. Furthermore, the paradoxical eating behavior induced orexin-A is illustrated in this minireview.

Keywords: behavior; body weight; energy expenditure; orexin-A; sympathetic nervous system.

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Figures

FIGURE 1
FIGURE 1
Effects of orexins in peripheral tissue and central nervous system.
FIGURE 2
FIGURE 2
Factors influencing eating behavior.
See this image and copyright information in PMC

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