Multiple intracranial fungal abscesses in an immunocompetent infant treated surgically

Abstract

Intracerebral abscess are rare in neonates and infants. We present a rare case of 4-month-old immunocompetent infant with multiple intracranial fungal abscess. Right frontoparietal craniotomy was done with excision of multicystic mass containing 200cc of dirty colored fluid. Biopsy and culture of abscess came as Aspergillus fumigates. Patient received parental amphotericin B. An immunocompetent infant with intracranial aspergillosis is rare. We advocate combination of surgical excision with parental amphotericin B as best way to achieve good result.

Keywords: Amphotericin B; Aspergillus; fungal abscess; infant; multiple.

Figure 1

Contrast-enhanced magnetic resonance imaging sagittal view showing heterointense ill-defined mass lesion in right fronto-temporal-parietal area with mild peripheral edema

Figure 2

Sections examined showed numerous granulomas with foreign-body type of giant cells. In one of the giant cells a pigmented septate hypha was seen. The morphological features were those of a aspergillosis [H and E, ×20]