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Case Reports
. 2014 May;9(2):188-91.
doi: 10.4103/1817-1745.139363.

Pituitary stalk interruption syndrome: Case report of three cases with review of literature

Manish Gutch  1 , Sukriti Kumar  2 , Syed Mohd Razi  1 , Sanjay Saran  1 , Keshav Kumar Gupta  1
Affiliations
Case Reports

Pituitary stalk interruption syndrome: Case report of three cases with review of literature

Manish Gutch et al. J Pediatr Neurosci. 2014 May.

Abstract

Pickardt syndrome (Pickardt-Fahlbusch syndrome) is a rare congenital syndrome characterized by tertiary hypothyroidism caused by the interruption of the portal veins between hypothalamus and adenohypophysis. Typical features of this syndrome are tertiary hypothyroidism with low thyroid stimulating hormone, hyperprolactinemia and other pituitary hormone deficiencies. Pituitary stalk interruption syndrome is characterized by a triad of thin or interrupted pituitary stalk, aplasia or hypoplasia of the anterior pituitary and absent or ectopic posterior pituitary (EPP) seen on magnetic resonance imaging (MRI). It is a congenital anomaly of pituitary whose exact prevalence is unknown. In some cases, it is restricted to EPP or pituitary stalk interruption. We are presenting the case history along with MRI finding of three children's who presented with short stature and delayed puberty.

Keywords: Delayed puberty; ectopic posterior pituitary; multiple pituitary hormones deficiency; pituitary stalk interruption syndrome.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Sagittal T1-weighted image shows ectopic posterior pituitary (white arrow), stalk not visualized
Figure 2
Figure 2
Postcontrast coronal T1-weighted image – pituitary stalk not visualised (note ectopic posterior pituitary-white arrow)
Figure 3
Figure 3
Sagittal T2-weighted image showing small anterior pituitary measuring 2.9 mm in height (black arrow)
Figure 4
Figure 4
Sagittal T2-weighted image showing anterior pituitary measuring 2.9 mm in height (white arrow)
Figure 5
Figure 5
Sagittal T1-weighted image showing ectopic posterior pituitary bright spot (white arrow)
Figure 6
Figure 6
Midline Sagittal T2-weighted image – pituitary stalk not visualized (white arrow)
See this image and copyright information in PMC

References

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