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Review
. 2014:2014:934605.
doi: 10.1155/2014/934605. Epub 2014 Aug 27.

Recent trends of polymer mediated liposomal gene delivery system

Shyamal Kumar Kundu  1 , Ashish Ranjan Sharma  2 , Sang-Soo Lee  2 , Garima Sharma  2 , C George Priya Doss  3 , Shin Yagihara  4 , Do-Young Kim  2 , Ju-Suk Nam  2 , Chiranjib Chakraborty  5
Affiliations
Review

Recent trends of polymer mediated liposomal gene delivery system

Shyamal Kumar Kundu et al. Biomed Res Int. 2014.

Retraction in

Abstract

Advancement in the gene delivery system have resulted in clinical successes in gene therapy for patients with several genetic diseases, such as immunodeficiency diseases, X-linked adrenoleukodystrophy (X-ALD) blindness, thalassemia, and many more. Among various delivery systems, liposomal mediated gene delivery route is offering great promises for gene therapy. This review is an attempt to depict a portrait about the polymer based liposomal gene delivery systems and their future applications. Herein, we have discussed in detail the characteristics of liposome, importance of polymer for liposome formulation, gene delivery, and future direction of liposome based gene delivery as a whole.

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Figures

Figure 1
Figure 1
Structure of liposome and schematic representation of the polymer modified liposomal gene delivery; (a) structure of liposome and its different phases: (i) gel phase and (ii) liquid crystalline phase; (b) schematic representation of the polymer modified liposomal gene vehicle preparation and release process after the delivery in the cell.
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