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Review
. 2014 Sep 23;6(9):3514-34.
doi: 10.3390/v6093514.

Role of microRNAs in arbovirus/vector interactions

Sassan Asgari  1
Affiliations
Review

Role of microRNAs in arbovirus/vector interactions

Sassan Asgari. Viruses. .

Abstract

The role of microRNAs (miRNAs) as small non-coding RNAs in regulation of gene expression has been recognized. They appear to be involved in regulation of a wide range of cellular pathways that affect several biological processes such as development, the immune system, survival, metabolism and host-pathogen interactions. Arthropod-borne viruses impose great economic and health risks around the world. Recent advances in miRNA biology have shed some light on the role of these small RNAs in vector-virus interactions. In this review, I will reflect on our current knowledge on the role of miRNAs in arbovirus-vector interactions and the potential avenues for their utilization in limiting virus replication and/or transmission.

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Figures

Figure 1
Figure 1
miRNAs are produced through canonical as well as non-canonical pathways.
Figure 2
Figure 2
aae-miR-2940-5p is a mosquito-specific miRNA that is highly induced in Wolbachia-infected mosquitoes. Three targets of this miRNA validated so far are metalloprotease ftsh, DNA methyltransferase Dnmt2 and Arginine methyltransferase 3 that are important in Wolbachia maintenance and/or affect arbovirus replication. Green arrows indicate induction/enhancement, whereas red colour indicates inhibition.
See this image and copyright information in PMC

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