Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2014 Dec;74(16):1579-88.
doi: 10.1002/pros.22871. Epub 2014 Sep 22.

8q24 risk alleles and prostate cancer in African-Barbadian men

Cheryl D Cropp  1 , Christiane M Robbins, Xin Sheng, Anselm J M Hennis, John D Carpten, Lyndon Waterman, Ronald Worrell, Tae-Hwi Schwantes-An, Jeffrey M Trent, Christopher A Haiman, M Cristina Leske, Suh-Yuh Wu, Joan E Bailey-Wilson, Barbara Nemesure
Affiliations
Meta-Analysis

8q24 risk alleles and prostate cancer in African-Barbadian men

Cheryl D Cropp et al. Prostate. 2014 Dec.

Abstract

Background: African American men (AA) exhibit a disproportionate share of prostate cancer (PRCA) incidence, morbidity, and mortality. Several genetic association studies have implicated select 8q24 loci in PRCA risk in AA. The objective of this investigation is to evaluate the association between previously reported 8q24 risk alleles and PRCA in African-Barbadian (AB) men known to have high rates of PRCA.

Methods: Ten previously reported candidate tag SNPs were genotyped and/or imputed in the 8q24 region in 532 AB men with PRCA and 513 AB controls from the Prostate Cancer in a Black Population (PCBP) study.

Results: Rs2124036 was significant in AB men, (OR = 2.7, 95% CI (1.3-5.3), P = 0.005, Empirical (max (T), corrected for multiple testing) P = 0.03) for the homozygous C/C genotype. Only a single SNP from this region remained statistically significant in our analysis of our AB population. These results may indicate the presence of a founder effect or due to the chosen SNPs not tagging an ancestral haplotype bearing the 8q24 risk allele(s) in this population or could reflect inadequate power to detect an association. We conducted a meta-analysis including our AB population along with two additional African Caribbean populations from Tobago and Jamaica for SNPs rs16901979 and rs1447295. Meta-analysis results were most significant for rs16901979 A allele (Z score 2.73; P = 0.006) with a summary OR = 1.31 (95% CI: 1.09-1.58).

Conclusions: Additional studies are needed to provide deeper genotype coverage to further interrogate the 8q24 region to understand its contribution to PRCA in this population.

Keywords: 8q24; Caribbean and risk factors; association; genetic; prostate cancer.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Haploview image for chromosome 8q24 from the PRCA association study of 10 SNPs. Note that the residual r2 pairwise linkage disequilibrium (LD) values from Haploview displayed above are multiplied times a factor of 100.
See this image and copyright information in PMC

References

    1. National Cancer Institute. SEER Incidence and US Mortality Statistics. 2012 http://seer.cancer.gov/statistics/
    1. Evans S, Metcalfe C, Ibrahim F, Persad R, Ben-Shlomo Y. Investigating Black-White differences in prostate cancer prognosis: A systematic review and meta-analysis. International journal of cancer Journal international du cancer. 2008;123(2):430–435. - PubMed
    1. Odedina FT, Akinremi TO, Chinegwundoh F, Roberts R, Yu D, Reams RR, Freedman ML, Rivers B, Green BL, Kumar N. Prostate cancer disparities in Black men of African descent: a comparative literature review of prostate cancer burden among Black men in the United States, Caribbean, United Kingdom, and West Africa. Infect Agent Cancerr. 2009;4(Suppl 1):S2. - PMC - PubMed
    1. Bock CH, Schwartz AG, Ruterbusch JJ, Levin AM, Neslund-Dudas C, Land SJ, Wenzlaff AS, Reich D, McKeigue P, Chen W, Heath EI, Powell IJ, Kittles RA, Rybicki BA. Results from a prostate cancer admixture mapping study in African-American men. Human genetics. 2009;126(5):637–642. - PMC - PubMed
    1. Chang BL, Spangler E, Gallagher S, Haiman CA, Henderson B, Isaacs W, Benford ML, Kidd LR, Cooney K, Strom S, Ingles SA, Stern MC, Corral R, Joshi AD, Xu J, Giri VN, Rybicki B, Neslund-Dudas C, Kibel AS, Thompson IM, Leach RJ, Ostrander EA, Stanford JL, Witte J, Casey G, Eeles R, Hsing AW, Chanock S, Hu JJ, John EM, Park J, Stefflova K, Zeigler-Johnson C, Rebbeck TR. Validation of genome-wide prostate cancer associations in men of African descent. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2011;20(1):23–32. - PMC - PubMed

Publication types

MeSH terms