Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014 Sep 24:14:707.
doi: 10.1186/1471-2407-14-707.

Physical activity and renal cell carcinoma among black and white Americans: a case-control study

Qian Xiao  1 , Linda Liao, Charles E Matthews, Wong-Ho Chow, Faith Davis, Kendra Schwartz, Mark Purdue, Jonathan N Hofmann, Joanne Colt
Affiliations

Physical activity and renal cell carcinoma among black and white Americans: a case-control study

Qian Xiao et al. BMC Cancer. .

Abstract

Background: Renal cell carcinoma (RCC) has a higher incidence in blacks than in whites. Physical activity may influence the risk of renal cell cancer, but the evidence is inconsistent. No previous study has investigated this relationship in the black population.

Methods: We examined the association between self-reported physical activity at different ages and risk of RCC in a population based case-control study of 1217 cases (361 black, 856 white) and 1235 controls (523 black, 712 white) frequency-matched on age, race, and gender. Multivariate-adjusted odds ratios (OR) and 95% confidence intervals (CI) were estimated using unconditional logistic regression.

Results: Among whites, increased risks of RCC were observed among participants reporting low levels of transportation-related activity in their 20's (OR <1 hr/wk vs >7 hr/wk (95% CI): 1.42 (1.10, 1.83)) and leisure time activity in their 50's (OR <1 hr/wk vs >7 hr/wk (95% CI): 1.49 (1.00, 2.20)). We found no association between physical activity and RCC risk among blacks.

Conclusion: Our results suggest that physical activity may be inversely associated with RCC risk in whites, but there was no evidence of such an association in blacks. As this is the first study evaluating the effect of physical activity on RCC risk among blacks, further investigations are needed to clarify the relationship in this population.

PubMed Disclaimer

References

    1. Siegel R, Naishadham D, Jemal A. Cancer statistics. CA Cancer J Clin. 2013;63(1):11–30. doi: 10.3322/caac.21166. - DOI - PubMed
    1. Chow WH, Devesa SS, Warren JL, Fraumeni JF., Jr Rising incidence of renal cell cancer in the United States. JAMA. 1999;281(17):1628–1631. doi: 10.1001/jama.281.17.1628. - DOI - PubMed
    1. Chow WH, Dong LM, Devesa SS. Epidemiology and risk factors for kidney cancer. Nat Rev Urol. 2010;7(5):245–257. doi: 10.1038/nrurol.2010.46. - DOI - PMC - PubMed
    1. Behrens G, Leitzmann MF. The association between physical activity and renal cancer: systematic review and meta-analysis. Br J Cancer. 2013;108(4):798–811. doi: 10.1038/bjc.2013.37. - DOI - PMC - PubMed
    1. Lindblad P, Wolk A, Bergstrom R, Persson I, Adami HO. The role of obesity and weight fluctuations in the etiology of renal cell cancer: a population-based case-control study. Cancer Epidemiol Biomarkers Prev. 1994;3(8):631–639. - PubMed
Pre-publication history
    1. The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2407/14/707/prepub

Publication types