. 2014 Oct 21;83(17):1530-7.

doi: 10.1212/WNL.0000000000000915. Epub 2014 Sep 24.

Long sleep duration in elders without dementia increases risk of dementia mortality (NEDICES)

Julián Benito-León¹, Elan D Louis², Alberto Villarejo-Galende², Juan P Romero², Félix Bermejo-Pareja²

Affiliations

¹ From the Department of Neurology (J.B.-L., A.V.-G., J.P.R., F.B.-P.), University Hospital 12 de Octubre, Madrid; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED) (J.B.-L., F.B.-P.), Spain; Department of Medicine (J.B.-L., A.V.-G., J.P.R., F.B.-P.), Complutense University, Madrid, Spain; G.H. Sergievsky Center (E.D.L.), Department of Neurology (E.D.L.), and Taub Institute for Research on Alzheimer's Disease and the Aging Brain (E.D.L.), College of Physicians and Surgeons, Columbia University; Department of Epidemiology (E.D.L.), Mailman School of Public Health, Columbia University, New York; and Faculty of Biosanitary Sciences (J.P.R.), Francisco de Vitoria University, Pozuelo de Alarcón, Madrid, Spain. jbenitol67@gmail.com.
² From the Department of Neurology (J.B.-L., A.V.-G., J.P.R., F.B.-P.), University Hospital 12 de Octubre, Madrid; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED) (J.B.-L., F.B.-P.), Spain; Department of Medicine (J.B.-L., A.V.-G., J.P.R., F.B.-P.), Complutense University, Madrid, Spain; G.H. Sergievsky Center (E.D.L.), Department of Neurology (E.D.L.), and Taub Institute for Research on Alzheimer's Disease and the Aging Brain (E.D.L.), College of Physicians and Surgeons, Columbia University; Department of Epidemiology (E.D.L.), Mailman School of Public Health, Columbia University, New York; and Faculty of Biosanitary Sciences (J.P.R.), Francisco de Vitoria University, Pozuelo de Alarcón, Madrid, Spain.

PMID: 25253755
PMCID: PMC4222849
DOI: 10.1212/WNL.0000000000000915

Long sleep duration in elders without dementia increases risk of dementia mortality (NEDICES)

Julián Benito-León et al. Neurology. 2014.

. 2014 Oct 21;83(17):1530-7.

doi: 10.1212/WNL.0000000000000915. Epub 2014 Sep 24.

Authors

Julián Benito-León¹, Elan D Louis², Alberto Villarejo-Galende², Juan P Romero², Félix Bermejo-Pareja²

Affiliations

¹ From the Department of Neurology (J.B.-L., A.V.-G., J.P.R., F.B.-P.), University Hospital 12 de Octubre, Madrid; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED) (J.B.-L., F.B.-P.), Spain; Department of Medicine (J.B.-L., A.V.-G., J.P.R., F.B.-P.), Complutense University, Madrid, Spain; G.H. Sergievsky Center (E.D.L.), Department of Neurology (E.D.L.), and Taub Institute for Research on Alzheimer's Disease and the Aging Brain (E.D.L.), College of Physicians and Surgeons, Columbia University; Department of Epidemiology (E.D.L.), Mailman School of Public Health, Columbia University, New York; and Faculty of Biosanitary Sciences (J.P.R.), Francisco de Vitoria University, Pozuelo de Alarcón, Madrid, Spain. jbenitol67@gmail.com.
² From the Department of Neurology (J.B.-L., A.V.-G., J.P.R., F.B.-P.), University Hospital 12 de Octubre, Madrid; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED) (J.B.-L., F.B.-P.), Spain; Department of Medicine (J.B.-L., A.V.-G., J.P.R., F.B.-P.), Complutense University, Madrid, Spain; G.H. Sergievsky Center (E.D.L.), Department of Neurology (E.D.L.), and Taub Institute for Research on Alzheimer's Disease and the Aging Brain (E.D.L.), College of Physicians and Surgeons, Columbia University; Department of Epidemiology (E.D.L.), Mailman School of Public Health, Columbia University, New York; and Faculty of Biosanitary Sciences (J.P.R.), Francisco de Vitoria University, Pozuelo de Alarcón, Madrid, Spain.

PMID: 25253755
PMCID: PMC4222849
DOI: 10.1212/WNL.0000000000000915

Abstract

Objective: To determine in a population-based study whether long sleep duration was associated with increased risk of dementia mortality.

Methods: In this prospective, population-based study of 3,857 people without dementia aged 65 years and older (NEDICES [Neurological Disorders in Central Spain]), participants reported their daily sleep duration. The average daily total sleep duration was grouped into 3 categories: ≤5 hours (short sleepers), 6-8 hours (reference category), and ≥9 hours (long sleepers). Community-dwelling elders were followed for a median of 12.5 years, after which the death certificates of those who died were examined.

Results: A total of 1,822 (47.2%) of 3,857 participants died, including 201 (11.0%) deaths among short sleepers, 832 (45.7%) among long sleepers, and 789 (43.3%) among those participants in the reference category. Of 1,822 deceased participants, 92 (5.1%) had a dementia condition reported on the death certificate (49 [53.3%] were long sleepers, 36 [39.1%] reported sleeping between 6 and 8 hours, and 7 [7.6%] were short sleepers). In an unadjusted Cox model, risk of dementia-specific mortality was increased in long sleepers (hazard ratio for dementia mortality in long sleepers = 1.58, p = 0.04) when compared with the reference group. In a Cox model that adjusted for numerous demographic factors and comorbidities, the hazard ratio for dementia mortality in long sleepers was 1.63 (p = 0.03).

Conclusions: Self-reported long sleep duration was associated with 58% increased risk of dementia-specific mortality in this cohort of elders without dementia. Future studies are required to confirm these findings.

PubMed Disclaimer

Figures

See this image and copyright information in PMC

Comment in

Author response.
Benito-León J, Louis ED, Villarejo-Galende A, Romero JP, Bermejo-Pareja F. Benito-León J, et al. Neurology. 2015 Jul 28;85(4):388. doi: 10.1212/WNL.0000000000001778. Neurology. 2015. PMID: 26215880 No abstract available.
Long sleep duration in elders without dementia increases risk of dementia mortality (NEDICES).
Kawada T. Kawada T. Neurology. 2015 Jul 28;85(4):388. Neurology. 2015. PMID: 26436153 No abstract available.

Cited by

Sex and age differences in the associations between sleep behaviors and all-cause mortality in older adults: results from the National Health and Nutrition Examination Surveys.
Beydoun HA, Beydoun MA, Chen X, Chang JJ, Gamaldo AA, Eid SM, Zonderman AB. Beydoun HA, et al. Sleep Med. 2017 Aug;36:141-151. doi: 10.1016/j.sleep.2017.05.006. Epub 2017 May 29. Sleep Med. 2017. PMID: 28735912 Free PMC article.
Sleep Duration and Neurocognitive Function in the Hispanic Community Health Study/Study of Latinos.
Ramos AR, Tarraf W, Daviglus M, Davis S, Gallo LC, Mossavar-Rahmani Y, Penedo FJ, Redline S, Rundek T, Sacco RL, Sotres-Alvarez D, Wright CB, Zee PC, González HM. Ramos AR, et al. Sleep. 2016 Oct 1;39(10):1843-1851. doi: 10.5665/sleep.6166. Sleep. 2016. PMID: 27450689 Free PMC article.
Self-Reported Sleep Duration and Pattern in Old Order Amish and Non-Amish Adults.
Zhang M, Ryan KA, Wickwire E, Postolache TT, Xu H, Daue M, Snitker S, Pollin TI, Shuldiner AR, Mitchell BD. Zhang M, et al. J Clin Sleep Med. 2019 Sep 15;15(9):1321-1328. doi: 10.5664/jcsm.7928. J Clin Sleep Med. 2019. PMID: 31538603 Free PMC article.
The Role of Lifestyle Factors and Sleep Duration for Late-Onset Dementia: A Cohort Study.
Larsson SC, Wolk A. Larsson SC, et al. J Alzheimers Dis. 2018;66(2):579-586. doi: 10.3233/JAD-180529. J Alzheimers Dis. 2018. PMID: 30320581 Free PMC article.
Insomnia and obstructive sleep apnea as potential triggers of dementia: is personalized prediction and prevention of the pathological cascade applicable?
Kitamura T, Miyazaki S, Sulaiman HB, Akaike R, Ito Y, Suzuki H. Kitamura T, et al. EPMA J. 2020 Jul 30;11(3):355-365. doi: 10.1007/s13167-020-00219-w. eCollection 2020 Sep. EPMA J. 2020. PMID: 32849926 Free PMC article. Review.

See all "Cited by" articles

References

1. Myers BL, Badia P. Changes in circadian rhythms and sleep quality with aging: mechanisms and interventions. Neurosci Biobehav Rev 1995;19:553–571. - PubMed
1. Ohayon MM, Vecchierini MF. Daytime sleepiness and cognitive impairment in the elderly population. Arch Intern Med 2002;162:201–208. - PubMed
1. Xu L, Jiang CQ, Lam TH, et al. Short or long sleep duration is associated with memory impairment in older Chinese: the Guangzhou Biobank Cohort Study. Sleep 2011;34:575–580. - PMC - PubMed
1. Ferrie JE, Shipley MJ, Akbaraly TN, Marmot MG, Kivimaki M, Singh-Manoux A. Change in sleep duration and cognitive function: findings from the Whitehall II Study. Sleep 2011;34:565–573. - PMC - PubMed
1. Virta JJ, Heikkila K, Perola M, et al. Midlife sleep characteristics associated with late life cognitive function. Sleep 2013;36:1533–1541. - PMC - PubMed

Publication types

Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Grants and funding

R01 NS039422/NS/NINDS NIH HHS/United States

LinkOut - more resources

Full Text Sources
Other Literature Sources
- scite Smart Citations
Medical
- MedlinePlus Health Information

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Long sleep duration in elders without dementia increases risk of dementia mortality (NEDICES)

Affiliations

Long sleep duration in elders without dementia increases risk of dementia mortality (NEDICES)

Authors

Affiliations

Abstract

Figures

Comment in

Similar articles

Cited by

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical