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Observational Study
. 2014 Sep 21;20(35):12615-20.
doi: 10.3748/wjg.v20.i35.12615.

Risk factors for combined hepatocellular-cholangiocarcinoma: a hospital-based case-control study

Yan-Ming Zhou  1 , Xiao-Feng Zhang  1 , Lu-Peng Wu  1 , Cheng-Jun Sui  1 , Jia-Mei Yang  1
Affiliations
Observational Study

Risk factors for combined hepatocellular-cholangiocarcinoma: a hospital-based case-control study

Yan-Ming Zhou et al. World J Gastroenterol. .

Abstract

Aim: To identify risk factors contributing to the development of combined hepatocellular-cholangiocarcinoma (CHC) in China.

Methods: One hundred and twenty-six patients with CHC and 4:1 matched healthy controls were interviewed during the period from February 2000 to October 2012. Logistic regression analysis was used to calculate odds ratios (OR) and 95% confidence intervals (CI) for each risk factor.

Results: Univariate analysis showed that the significant risk factors for CHC development were hepatitis B virus (HBV) infection, heavy alcohol consumption, a family history of liver cancer, and diabetes mellitus. Multivariate stepwise logistic regression analysis showed that HBV infection (OR = 19.245, 95%CI: 13.260-27.931) and heavy alcohol consumption (OR = 2.186, 95%CI: 1.070-4.466) were independent factors contributing to the development of CHC.

Conclusion: HBV infection and heavy alcohol consumption may play a role in the development of CHC in China.

Keywords: Alcohol consumption; Combined hepatocellular-cholangiocarcinoma; Epidemiology; Hepatitis B virus; Risk factors.

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