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. 2014:2014:906723.
doi: 10.1155/2014/906723. Epub 2014 Aug 28.

Maternal opioid drug use during pregnancy and its impact on perinatal morbidity, mortality, and the costs of medical care in the United States

Valerie E Whiteman  1 , Jason L Salemi  2 , Mulubrhan F Mogos  3 , Mary Ashley Cain  1 , Muktar H Aliyu  4 , Hamisu M Salihu  5
Affiliations

Maternal opioid drug use during pregnancy and its impact on perinatal morbidity, mortality, and the costs of medical care in the United States

Valerie E Whiteman et al. J Pregnancy. 2014.

Abstract

Objective: To identify factors associated with opioid use during pregnancy and to compare perinatal morbidity, mortality, and healthcare costs between opioid users and nonusers.

Methods: We conducted a cross-sectional analysis of pregnancy-related discharges from 1998 to 2009 using the largest publicly available all-payer inpatient database in the United States. We scanned ICD-9-CM codes for opioid use and perinatal outcomes. Costs of care were estimated from hospital charges. Survey logistic regression was used to assess the association between maternal opioid use and each outcome; generalized linear modeling was used to compare hospitalization costs by opioid use status.

Results: Women who used opioids during pregnancy experienced higher rates of depression, anxiety, and chronic medical conditions. After adjusting for confounders, opioid use was associated with increased odds of threatened preterm labor, early onset delivery, poor fetal growth, and stillbirth. Users were four times as likely to have a prolonged hospital stay and were almost four times more likely to die before discharge. The mean per-hospitalization cost of a woman who used opioids during pregnancy was $5,616 (95% CI: $5,166-$6,067), compared to $4,084 (95% CI: $4,002-$4,166) for nonusers.

Conclusion: Opioid use during pregnancy is associated with adverse perinatal outcomes and increased healthcare costs.

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Figures

Figure 1
Figure 1
Rates (per 1,000 pregnancy-related discharges) of selected comorbidities, by opioid use status, among pregnancy-related discharges, NIS, 1998–2009. HIV = human immunodeficiency virus, NIS = Nationwide Inpatient Sample
See this image and copyright information in PMC

References

    1. Kuehn BM. Opioid prescriptions soar: increase in legitimate use as well as abuse. The Journal of the American Medical Association. 2007;297(3):249–251. - PubMed
    1. Benningfield MM, Arria AM, Kaltenbach K, et al. Co-occurring psychiatric symptoms are associated with increased psychological, social, and medical impairment in opioid dependent pregnant women. The American Journal on Addictions. 2010;19(5):416–421. - PMC - PubMed
    1. Kaltenbach K, Berghella V, Finnegan L. Opioid dependence during pregnancy: effects and management. Obstetrics and Gynecology Clinics of North America. 1998;25(1):139–151. - PubMed
    1. Benningfield MM, Dietrich MS, Jones HE, et al. Opioid dependence during pregnancy: relationships of anxiety and depression symptoms to treatment outcomes. Addiction. 2012;107(supplement 1):74–82. - PMC - PubMed
    1. Shainker SA, Saia K, Lee-Parritz A. Opioid addiction in pregnancy. Obstetrical and Gynecological Survey. 2012;67(12):817–825. - PubMed

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