Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2014:2014:639058.
doi: 10.1155/2014/639058. Epub 2014 Sep 1.

Impact of the prolymphangiogenic crosstalk in the tumor microenvironment on lymphatic cancer metastasis

Simona L Schlereth  1 , Nasrin Refaian  1 , Sandra Iden  2 , Claus Cursiefen  1 , Ludwig M Heindl  1
Affiliations
Review

Impact of the prolymphangiogenic crosstalk in the tumor microenvironment on lymphatic cancer metastasis

Simona L Schlereth et al. Biomed Res Int. 2014.

Abstract

Lymphangiogenesis is a very early step in lymphatic metastasis. It is regulated and promoted not only by the tumor cells themselves, but also by cells of the tumor microenvironment, including cancer associated fibroblasts, mesenchymal stem cells, dendritic cells, or macrophages. Even the extracellular matrix as well as cytokines and growth factors are involved in the process of lymphangiogenesis and metastasis. The cellular and noncellular components influence each other and can be influenced by the tumor cells. The knowledge about mechanisms behind lymphangiogenesis in the tumor microenvironmental crosstalk is growing and offers starting points for new therapeutic approaches.

PubMed Disclaimer

Figures

Figure 1
Figure 1
The prolymphangiogenic crosstalk of the tumor microenvironment: tumor cells as well as macrophages, dendritic cells, the extracellular matrix, cancer-associated fibroblasts, and mesenchymal stem cells can promote lymphangiogenesis by secretion or expression of different factors.
See this image and copyright information in PMC

References

    1. Shields JD, Borsetti M, Rigby H, et al. Lymphatic density and metastatic spread in human malignant melanoma. British Journal of Cancer. 2004;90(3):693–700. - PMC - PubMed
    1. Beasley NJP, Prevo R, Banerji S, et al. Intratumoral lymphangiogenesis and lymph node metastasis in head and neck cancer. Cancer Research. 2002;62(5):1315–1320. - PubMed
    1. Beckmann MW, Mehlhorn G, Thiel F, Breuel C, Fasching PA, Ackermann S. Therapiefortschritte beim primären Zervixkarzinom. Deutsches Ärzteblatt. 2005;102:A979–A986.
    1. Sundlisæter E, Dicko A, Sakariassen PØ, Sondenaa K, Enger PØ, Bjerkvig R. Lymphangiogenesis in colorectal cancer—prognostic and therapeutic aspects. International Journal of Cancer. 2007;121(7):1401–1409. - PubMed
    1. Bruce J, Carter DC, Fraser J. Patterns of recurrent disease in breast cancer. The Lancet. 1970;1(7644):433–435. - PubMed

Publication types

MeSH terms

LinkOut - more resources