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Comparative Study
. 2014 Sep 25;9(9):e107620.
doi: 10.1371/journal.pone.0107620. eCollection 2014.

Falls in people with multiple sclerosis compared with falls in healthy controls

Rajarshi Mazumder  1 , Charles Murchison  2 , Dennis Bourdette  3 , Michelle Cameron  3
Affiliations
Comparative Study

Falls in people with multiple sclerosis compared with falls in healthy controls

Rajarshi Mazumder et al. PLoS One. .

Abstract

Objective: To compare the risk, circumstances, consequences and causes of prospectively recorded falls between people with multiple sclerosis (PwMS) and healthy controls of similar age and gender.

Methods: 58 PwMS and 58 healthy controls, who are community-dwelling, were recruited in this 6-month prospective cohort study. 90% of PwMS and 84% of healthy controls completed the study. Participants counted falls prospectively using fall calendars and noted fall location, fall-related injuries, and the cause of the falls. Kaplan Meier survival analysis and log-rank tests were performed to compare the distributions of survival without falling between PwMS and healthy controls.

Results: 40.8% of controls and 71.2% of PwMS fell at least once. 48.1% of PwMS and 18.4% of healthy controls fell at least twice. 42.3% of PwMS and 20.4% of health controls sustained a fall-related injury. After adjusting for age and gender, the time to first fall (HR: 1.87, p = 0.033) and the time to recurrent falls (HR: 2.87, p = 0.0082) were significantly different between PwMS and healthy controls. PwMS reported an almost equal number of falls inside and outside, 86% of the falls in healthy controls were outside. Healthy controls were more likely to fall due to slipping on a slippery surface (39.5% vs 10.4%). PwMS more often attributed falls to distraction (31% vs 7%) and uniquely attributed falls to fatigue or heat.

Conclusions: Fall risk, circumstances, consequences, and causes are different for PwMS than for healthy people of the same age and gender. PwMS fall more, are more likely to be injured by a fall, and often fall indoors. PwMS, but not healthy controls, frequently fall because they are distracted, fatigued or hot.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Participant flow diagram.
Figure 2
Figure 2. Frequency of falls in participants with MS and healthy controls.
(A) in participants with MS (n = 52, No falls in 28.8%, 1 fall in 23.1%, 2 falls in 9.6% and 3–10 falls in 34.6%); (B) in healthy controls (n = 49, No falls in 57.1%, 1 fall in 24.5%, 2 falls in 8.2%, 3–10 falls in 8.2%).
Figure 3
Figure 3. Kaplan-Meier survival curves for A) Time to first fall, and B) Time to recurrent falls in people with MS and healthy controls.
See this image and copyright information in PMC

References

    1. Cattaneo D, De Nuzzo C, Fascia T, Macalli M, Pisoni I, et al. (2002) Risks of falls in subjects with multiple sclerosis. Arch Phys Med Rehabil 83: 864–867. - PubMed
    1. Finlayson ML, Peterson EW, Cho CC (2006) Risk factors for falling among people aged 45 to 90 years with multiple sclerosis. Arch Phys Med Rehabil 87: 1274–1279. - PubMed
    1. Gunn H, Creanor S, Haas B, Marsden J, Freeman J (2014) Frequency, characteristics and consequences of falls in multiple sclerosis: Findings from a cohort study. Arch Phys Med Rehabil 95: 538–45. - PubMed
    1. Hoang PD, Cameron MH, Gandevia SC, Lord SR (2014) Neuropsychological, balance, and mobility risk factors for falls in people with multiple sclerosis: A prospective cohort study. Arch Phys Med Rehabil 95: 480–6. - PubMed
    1. Matsuda PN, Shumway-Cook A, Bamer AM, Johnson SL, Amtmann D, et al. (2011) Falls in multiple sclerosis. PM R 3: 624–32. - PubMed

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