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. 2014 Oct 17;16(20):5342-5.
doi: 10.1021/ol502524d. Epub 2014 Sep 25.

Metal-free oxidative C(sp3)-H bond functionalization of alkanes and conjugate addition to chromones

Jincan Zhao  1 , Hong Fang, Ping Qian, Jianlin Han, Yi Pan
Affiliations

Metal-free oxidative C(sp3)-H bond functionalization of alkanes and conjugate addition to chromones

Jincan Zhao et al. Org Lett. .

Abstract

A metal-free oxidative C(sp(3))-H bond functionalization and subsequent conjugate addition reaction using di-tert-butyl peroxide (DTBP) as the oxidant was established, which tolerates a wide range of simple alkane substrates to react with different substituted chromones for direct preparation of 2-alkylchromanones.

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