Subjective cognitive concerns, episodic memory, and the APOE ε4 allele

Cécilia Samieri¹, Cécile Proust-Lima², Maria M Glymour³, Olivia I Okereke⁴, Rebecca E Amariglio⁵, Reisa A Sperling⁵, Dorene M Rentz⁵, Francine Grodstein⁶

Affiliations

¹ Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; INSERM, Centre INSERM U897-Epidémiologie-Biostatistiques, Bordeaux, France; Univ. Bordeaux, Centre INSERM U897-Epidémiologie-Biostatistiques, Bordeaux, France. Electronic address: cecilia.samieri@channing.harvard.edu.
² INSERM, Centre INSERM U897-Epidémiologie-Biostatistiques, Bordeaux, France; Univ. Bordeaux, Centre INSERM U897-Epidémiologie-Biostatistiques, Bordeaux, France.
³ Department of Social & Behavioral Sciences, Harvard School of Public Health, Boston, MA, USA; Department of Epidemiology & Biostatistics, University of California San Francisco, San Francisco, CA, USA.
⁴ Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA; Department of Psychiatry, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA.
⁵ Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.
⁶ Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA.

PMID: 25256133
PMCID: PMC4253880
DOI: 10.1016/j.jalz.2014.06.012

Subjective cognitive concerns, episodic memory, and the APOE ε4 allele

Cécilia Samieri et al. Alzheimers Dement. 2014 Nov.

. 2014 Nov;10(6):752-759.e1.

doi: 10.1016/j.jalz.2014.06.012. Epub 2014 Sep 23.

Authors

Cécilia Samieri¹, Cécile Proust-Lima², Maria M Glymour³, Olivia I Okereke⁴, Rebecca E Amariglio⁵, Reisa A Sperling⁵, Dorene M Rentz⁵, Francine Grodstein⁶

Affiliations

¹ Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; INSERM, Centre INSERM U897-Epidémiologie-Biostatistiques, Bordeaux, France; Univ. Bordeaux, Centre INSERM U897-Epidémiologie-Biostatistiques, Bordeaux, France. Electronic address: cecilia.samieri@channing.harvard.edu.
² INSERM, Centre INSERM U897-Epidémiologie-Biostatistiques, Bordeaux, France; Univ. Bordeaux, Centre INSERM U897-Epidémiologie-Biostatistiques, Bordeaux, France.
³ Department of Social & Behavioral Sciences, Harvard School of Public Health, Boston, MA, USA; Department of Epidemiology & Biostatistics, University of California San Francisco, San Francisco, CA, USA.
⁴ Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA; Department of Psychiatry, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA.
⁵ Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.
⁶ Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA.

PMID: 25256133
PMCID: PMC4253880
DOI: 10.1016/j.jalz.2014.06.012

Abstract

Background: Subjective cognitive concerns may represent a simple method to assess likelihood of memory decline among apolipoprotein E (APOE) ε4 carriers.

Methods: We examined the relationship of self-reported subjective cognitive concerns, using seven specific cognitive concerns, with memory and memory decline over 6 years among APOE ε4 carriers and non-carriers from the Nurses' Health Study.

Results: In both groups, increasing subjective cognitive concern score predicted worse baseline memory and faster rates of subsequent memory decline, after adjustment for age, education and depression. The relation with baseline memory appeared statistically stronger in APOE ε4 carriers (P-interaction = 0.03). For memory decline, mean differences in slopes of episodic memory (95% CI) for 4 to 7 versus no concern = -0.05 (-0.10, 0.01) standard units in APOE ε4 carriers, and -0.04 (-0.08, -0.01) standard units in non-carriers.

Conclusions: APOE ε4 carriers with self-assessed cognitive concerns appear to have worse memory, and possibly accelerated memory decline.

Keywords: Apolipoprotein E4; Memory; Subjective cognitive concerns.

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Conflict of interest statement

All the authors read the draft critically. The authors report no conflict of interest.

Figures

Figure. Trajectories of episodic memory composite score, by increasing number of subjective cognitive concerns reported at baseline among APOE ε4 carriers and non-carriers.*
* Trajectories were estimated using a linear mixed model adjusted for age, educational level and mental health index (MHI-5). Predicted mean evolution of composite episodic memory scores were represented for registered nurses, aged 70 years-old, with a MHI-5 score=83 (ie, the average score in the population), and APOE4 carriers (left) and non-carriers (right), respectively. P-values for trend were calculated using a continuous variable of concerns score in another multivariate linear mixed model.

See this image and copyright information in PMC

References

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Subjective cognitive concerns, episodic memory, and the APOE ε4 allele

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Subjective cognitive concerns, episodic memory, and the APOE ε4 allele

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