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Comment
. 2014 Oct 27;53(44):11696-8.
doi: 10.1002/anie.201407921. Epub 2014 Sep 24.

Aspergillomarasmine A, an inhibitor of bacterial metallo-β-lactamases conferring blaNDM and blaVIM resistance

Franz von Nussbaum  1 , Guido Schiffer
Affiliations
Comment

Aspergillomarasmine A, an inhibitor of bacterial metallo-β-lactamases conferring blaNDM and blaVIM resistance

Franz von Nussbaum et al. Angew Chem Int Ed Engl. .

Abstract

Silencing the deadly "bla-bla" of superbugs: The natural product aspergillomarasmine A (AMA) showed in vivo efficacy against Enterobacteriaceae, conferring broad β-lactam resistance blaNDM-1 (NDM-1: New Delhi Metallo-β-lactamase 1). In rodents, the natural product restored efficacy of the gold standard meropenem by inhibition of the Zn-containing active site in NDM-1.

Keywords: amino acids; antibiotics; lactams; natural products; zinc.

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