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Review
. 2014 Aug 18;6(3):1705-26.
doi: 10.3390/cancers6031705.

Human papillomavirus in head and neck cancer

Anna Rosa Garbuglia  1
Affiliations
Review

Human papillomavirus in head and neck cancer

Anna Rosa Garbuglia. Cancers (Basel). .

Abstract

Human papillomavirus (HPV) is currently considered to be a major etiologic factor, in addition to tobacco and alcohol, for oropharyngeal cancer (OPC) development. HPV positive OPCs are epidemiologically distinct from HPV negative ones, and are characterized by younger age at onset, male predominance, and strong association with sexual behaviors. HPV16 is the most prevalent types in oral cavity cancer (OCC), moreover the prevalence of beta, and gamma HPV types is higher than that of alpha HPV in oral cavity.

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Figures

Figure 1
Figure 1
Phylogenetic tree constructed from the alignement of 384 nucleotides in the E6 genes of 28 HPVs using maximum parsimony analysis (PAUP 3.0). The labels on the right indicate the corresponding clinical category associated with each HPV type. (From Van Ranst et al. [4]).
See this image and copyright information in PMC

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