Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2014 Oct;46(10):1048-9.
doi: 10.1038/ng.3100.

NLRC4 gets out of control

Hanif Javanmard Khameneh  1 , Alessandra Mortellaro  1
Affiliations
Comment

NLRC4 gets out of control

Hanif Javanmard Khameneh et al. Nat Genet. 2014 Oct.

Abstract

The NLRC4 inflammasome mediates the rapid release of proinflammatory cytokines in response to various microbial stimuli, but its role in the pathology of human diseases remains unknown. Two new studies now report gain-of-function mutations in the NLRC4 gene that cosegregate with distinct autoinflammatory syndromes in affected families.

PubMed Disclaimer

Comment on

References

    1. Nature. 2011 Sep 14;477(7366):596-600 - PubMed
    1. Nat Genet. 2014 Oct;46(10):1140-6 - PubMed
    1. Genomics. 2001 Jul;75(1-3):77-83 - PubMed
    1. Nature. 2004 Jul 8;430(6996):213-8 - PubMed
    1. J Exp Med. 2007 Dec 24;204(13):3235-45 - PubMed

LinkOut - more resources