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. 2015 Feb;30(2):272-6.
doi: 10.1016/j.arth.2014.08.022. Epub 2014 Sep 6.

Venous thromboembolism and mortality associated with tranexamic acid use during total hip and knee arthroplasty

Christopher M Duncan  1 , Blake P Gillette  2 , Adam K Jacob  1 , Rafael J Sierra  3 , Joaquin Sanchez-Sotelo  3 , Hugh M Smith  1
Affiliations

Venous thromboembolism and mortality associated with tranexamic acid use during total hip and knee arthroplasty

Christopher M Duncan et al. J Arthroplasty. 2015 Feb.

Abstract

TKA and THA are associated with blood transfusion and risk for postoperative venothromboembolism (VTE). Reports show that tranexamic acid (TA) may be safe to use in high-risk orthopedic patients, but further data are needed to substantiate its use. All patients who underwent primary or revision TKA or THA in a five year period were retrospectively identified. In 13,262 elective TKA or THA procedures, neither the odds of VTE (OR=0.98; 95% CI 0.67-1.45; P=0.939) or adjusted odds of death (OR=0.26; 95% CI 0.04-1.80; P=0.171) were significant with TA administration. The major findings of this large, single center, retrospective cohort study show the odds of postoperative VTE and 30-day mortality were unchanged with TA administration.

Keywords: hip arthroplasty; knee arthroplasty; mortality; tranexamic acid; venothromboembolism.

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