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Review
. 2014 Sep 1;15(9):15358-76.
doi: 10.3390/ijms150915358.

The aging kidney: increased susceptibility to nephrotoxicity

Xinhui Wang  1 , Joseph V Bonventre  2 , Alan R Parrish  3
Affiliations
Review

The aging kidney: increased susceptibility to nephrotoxicity

Xinhui Wang et al. Int J Mol Sci. .

Abstract

Three decades have passed since a series of studies indicated that the aging kidney was characterized by increased susceptibility to nephrotoxic injury. Data from these experimental models is strengthened by clinical data demonstrating that the aging population has an increased incidence and severity of acute kidney injury (AKI). Since then a number of studies have focused on age-dependent alterations in pathways that predispose the kidney to acute insult. This review will focus on the mechanisms that are altered by aging in the kidney that may increase susceptibility to injury, including hemodynamics, oxidative stress, apoptosis, autophagy, inflammation and decreased repair.

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Figures

Figure 1
Figure 1
Causes of increased incidence of acute kidney injury (AKI) with aging.
Figure 2
Figure 2
Mechanisms of increased incidence of AKI with aging.
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