Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Jan;31(1):36-44.
doi: 10.1089/AID.2014.0236.

Progress towards an HIV cure: update from the 2014 International AIDS Society Symposium

Jenny Louise Anderson  1 , Rémi Fromentin, Giulio Maria Corbelli, Lars Østergaard, Anna Laura Ross
Affiliations

Progress towards an HIV cure: update from the 2014 International AIDS Society Symposium

Jenny Louise Anderson et al. AIDS Res Hum Retroviruses. 2015 Jan.

Abstract

Biomedical research has led to profound advances in the treatment of HIV infection. Combination antiretroviral therapy (ART) now provides the means to readily control viral infection, and people living with HIV who receive timely and effective ART can expect to benefit from a life expectancy comparable to uninfected individuals. Nevertheless, despite effective treatment, ART does not fully restore the immune system and importantly HIV persists indefinitely in latent reservoirs, resulting in the need for life-long treatment. The challenges and limits of life-long treatment have spurred significant scientific interest and global investment into research towards an HIV cure. The International AIDS Society (IAS) 2014 Towards an HIV cure symposium brought together researchers and community to discuss the most recent advances in our understanding of latency and HIV reservoirs, and the clinical approaches towards an HIV cure under current investigation. This report summarizes and reviews some of the major findings discussed during the symposium.

PubMed Disclaimer

References

    1. Henrich TJ, Hanhauser E, Marty FM, et al. : Antiretroviral-free HIV-1 remission and viral rebound after allogeneic stem cell transplantation: Report of 2 cases. Ann Intern Med 2014;161(5):319–327 - PMC - PubMed
    1. Henrich TJ, Hu Z, Li JZ, et al. : Long-term reduction in peripheral blood HIV type 1 reservoirs following reduced-intensity conditioning allogeneic stem cell transplantation. J Infect Dis 2013;207(11):1694–1702 - PMC - PubMed
    1. Fennessey CR. and Keele B: Ultra-deep barcoded SIVmac259 to identify and quantify viral reservoirs and recrudescent viremia. 2014IAS Towards an HIV cure symposium Melbourne, Australia, 2014
    1. Hecht FM. and Palmer S: Genetically characterizing the role of cell proliferation in maintaining persistent HIV during effective HIV therapy. 2014IAS Towards an HIV cure symposium Melbourne, Australia, 2014
    1. Fromentin R, Bakeman W, Lawani MB, et al. :. The immune checkpoint blockers PD-1, LAG-3 and TIGIT are biomarkers of HIV infected cells during ART and identify distinct cellular reservoirs. 2014IAS Towards an HIV cure symposium Melbourne, Australia, 2014

Publication types

MeSH terms

LinkOut - more resources