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. 2014 Nov 28;12(44):8861-5.
doi: 10.1039/c4ob01644k.

Solvent switchable cycloaddition: a (one-pot) metal-free approach towards N-substituted benzo[e]- or [f]isoindolones via C(sp(2))-H functionalization

Pratik A Ambasana  1 , Dipak D Vachhani, Marzia Galli, Jeroen Jacobs, Luc Van Meervelt, Anamik K Shah, Erik V Van der Eycken
Affiliations

Solvent switchable cycloaddition: a (one-pot) metal-free approach towards N-substituted benzo[e]- or [f]isoindolones via C(sp(2))-H functionalization

Pratik A Ambasana et al. Org Biomol Chem. .

Abstract

The tuning of selective ring closure is a nontrivial challenge in synthetic organic chemistry. Herein we report a solvent switchable metal-free [4 + 2] cycloaddition approach via Csp(2)-H functionalization. The protocol is highly atom economical with water being the only by-product, delivering N-substituted benzo[e]- or [f]isoindolones in high yields.

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