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. 2014:2014:831398.
doi: 10.1155/2014/831398. Epub 2014 Sep 1.

Cooccurrence of Darier's Disease and Epilepsy: A Pediatric Case Report and Review of the Literature

Tamer Celik  1 , Umit Celik  2 , Cigdem Donmezer  2 , Mustafa Komur  1 , Orkun Tolunay  2 , Pelin Demirtürk  3
Affiliations

Cooccurrence of Darier's Disease and Epilepsy: A Pediatric Case Report and Review of the Literature

Tamer Celik et al. Case Rep Pediatr. 2014.

Abstract

Darier's disease is a skin disorder characterized by multiple eruptions of hyperkeratosis or crusted papules at seborrheic areas with histologic acantholysis and dyskeratosis. It is caused by mutations in a single gene, being ATP2A2 and that is expressed in the skin and brain. The cooccurrence of various neurologic and psychiatric diseases with Darier's disease has been reported frequently in literature. They include mood disorders, epilepsy, encephalopathy, and schizophrenia. In this study, we report a pediatric case with the cooccurrence of Darier's disease and epilepsy. We also revised current English literature on this topic.

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Figures

Figure 1
Figure 1
Hyperkeratotic dark papules on the neck.
Figure 2
Figure 2
Skin biopsy showing hyperkeratosis, dyskeratosis, papillomatosis, suprabasal acantholysis, and dermal chronic inflammatory infiltrate (H&E ×100).
See this image and copyright information in PMC

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