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Comment
. 2014 Sep 25;159(1):13-14.
doi: 10.1016/j.cell.2014.09.005.

Biogenesis of Circular RNAs

Quentin Vicens  1 , Eric Westhof  2
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Free article
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Biogenesis of Circular RNAs

Quentin Vicens et al. Cell. .
Free article

Abstract

Circular RNAs are generated during splicing through various mechanisms. Ashwal-Fluss et al. demonstrate that exon circularization and linear splicing compete with each other in a tissue-specific fashion, and Zhang et al. show that exon circularization depends on flanking intronic complementary sequences. Both papers show that several types of circular RNA transcripts can be produced from a single gene.

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  • circRNA biogenesis competes with pre-mRNA splicing.
    Ashwal-Fluss R, Meyer M, Pamudurti NR, Ivanov A, Bartok O, Hanan M, Evantal N, Memczak S, Rajewsky N, Kadener S. Ashwal-Fluss R, et al. Mol Cell. 2014 Oct 2;56(1):55-66. doi: 10.1016/j.molcel.2014.08.019. Epub 2014 Sep 18. Mol Cell. 2014. PMID: 25242144

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