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. 1989;21(3):265-78.
doi: 10.1016/0020-711x(89)90184-5.

Study of the N-glycoprotein biosynthesis through dolichol intermediates in the mitochondrial membranes

C Levrat  1 , D Ardail, R Morelis, P Louisot
Affiliations

Study of the N-glycoprotein biosynthesis through dolichol intermediates in the mitochondrial membranes

C Levrat et al. Int J Biochem. 1989.

Abstract

1. In the mitochondria, the biosynthesis of N-glycoprotein products, through the dolichol intermediates pathway, appears in the outer and in the inner membranes. 2. The biosynthesis of dolichol-pyrophosphoryl-N-acetyl-glucosamine, dolichol-pyrophosphoryl-di-N-acetylchitobiose, dolichol-phosphoryl-glucose and dolichol-phosphoryl-mannose is effective in both membranes. 3. The lipid-linked oligosaccharides biosynthesized in both membranes contain high mannose-type oligosaccharides ranging in size from Man9-GlcNac2 to Man4-GlcNac2. 4. The assembly of the dolichol-pyrophosphoryl-oligosaccharides on the trimannosidic core begins by the elongation of the alpha-1,3 mannose branch in the outer membrane and of the alpha-1,6 mannose branch in the inner membrane.

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