Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Multicenter Study
. 2015 Jan;100(1):e32-4.
doi: 10.3324/haematol.2014.115394. Epub 2014 Sep 26.

Circadian and circannual variations in cord blood hematopoietic cell composition

Sophie Servais  1 , Etienne Baudoux  1 , Bénédicte Brichard  2 , Dominique Bron  3 , Cécile Debruyn  3 , Didier De Hemptinne  4 , Véronique Deneys  2 , Jean-Michel Paulus  1 , Jean-Pierre Schaaps  1 , Jean-Remy Van Cauwenberge  1 , Laurence Seidel  1 , Alain Delforge  3 , Yves Beguin  5
Affiliations
Multicenter Study

Circadian and circannual variations in cord blood hematopoietic cell composition

Sophie Servais et al. Haematologica. 2015 Jan.
No abstract available

Keywords: circadian variations; circannual variations; cord blood; hematopoietic stem cells.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Hematopoietic cell concentrations in cord blood (CB) according to time of day of delivery (A) and month of delivery (B). Means with 95% confidence intervals are shown. P values in parentheses are adjusted for the center. (A) Overall, 61 CB units were collected between 0:00 and 4:00, 101 between 4:00 and 8:00, 270 between 8:00 and 12:00, 378 between 12:00 and 16:00, 160 between 16:00 and 20:00 and 90 between 20:00 and 24:00. Data concerning time of delivery were missing for 67 CB units. BFU-E and CFU-Mix colonies were only measured for CB units analyzed in Center 2 (12 units collected between 0:00 and 4:00, 43 between 4:00 and 8:00, 144 between 8:00 and 12:00, 163 between 12:00 and 16:00, 31 between 16:00 and 20:00 and 16 between 20:00 and 24:00). (B) Overall, 198 CB units were collected in January-February, 224 in March–April, 247 in May–June, 143 in July–August, 146 in September–October and 169 in November–December. BFU-E and CFU-Mix colonies were only measured for CB units analyzed in Center 2 (94 units collected in January–February, 64 in March–April, 97 in May–June, 36 in July–August, 59 in September–October and 59 in November–December). J–F: January–February; M–A: March–April; M–J: May–June; J–A: July–August; S–O: September–October; N–D: November–December. NS: not significant. Question mark indicates that the measurements should be interpreted with caution because they were based on a small sample.
See this image and copyright information in PMC

References

    1. Barker JN, Scaradavou A, Stevens CE. Combined effect of total nucleated cell dose and HLA match on transplantation outcome in 1061 cord blood recipients with hematologic malignancies. Blood. 2010;115(9):1843–9. - PMC - PubMed
    1. Page KM, Zhang L, Mendizabal A, Wease S, Carter S, Gentry T, et al. Total colony-forming units are a strong, independent predictor of neutrophil and platelet engraftment after unrelated umbilical cord blood transplantation: a single-center analysis of 435 cord blood transplants. Biol Blood Marrow Transplant. 2011;17(9):1362–74. - PubMed
    1. Rodrigues CA, Sanz G, Brunstein CG, Sanz J, Wagner JE, Renaud M, et al. Analysis of risk factors for outcomes after unrelated cord blood transplantation in adults with lymphoid malignancies: a study by the Eurocord-Netcord and lymphoma working party of the European group for blood and marrow transplantation. J Clin Oncol. 2009; 27(2):256–63. - PubMed
    1. Cairo MS, Wagner EL, Fraser J, Cohen G, van de Ven C, Carter SL, et al. Characterization of banked umbilical cord blood hematopoietic progenitor cells and lymphocyte subsets and correlation with ethnicity, birth weight, sex, and type of delivery: a Cord Blood Transplantation (COBLT) Study report. Transfusion. 2005;45(6):856–66. - PubMed
    1. Keersmaekers CL, Mason BA, Keersmaekers J, Ponzini M, Mlynarek RA. Factors affecting umbilical cord blood stem cell suitability for transplantation in an in utero collection program. Transfusion. 2014; 54(3):545–9. - PubMed