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Randomized Controlled Trial
. 2015 Jan;159(1):64-70.e1-2.
doi: 10.1016/j.ajo.2014.09.028. Epub 2014 Sep 28.

Stereopsis results at 4.5 years of age in the infant aphakia treatment study

E Eugenie Hartmann  1 , Ann U Stout  2 , Michael J Lynn  3 , Kimberly G Yen  4 , Stacey J Kruger  5 , Scott R Lambert  6 ; Infant Aphakia Treatment Study Group; Infant Aphakia Treatment Study Group
Collaborators, Affiliations
Randomized Controlled Trial

Stereopsis results at 4.5 years of age in the infant aphakia treatment study

E Eugenie Hartmann et al. Am J Ophthalmol. 2015 Jan.

Abstract

Purpose: To determine whether stereopsis of infants treated for monocular cataracts varies with the type of optical correction used.

Design: Randomized prospective clinical trial.

Methods: The Infant Aphakia Treatment Study randomized 114 patients with unilateral cataracts at age 1-7 months to either primary intraocular lens (IOL) or contact lens correction. At 4.5 years of age a masked examiner assessed stereopsis on these patients using 3 different tests: (1) Frisby; (2) Randot Preschool; and (3) Titmus Fly.

Results: Twenty-eight patients (25%) had a positive response to at least 1 of the stereopsis tests. There was no statistically significant difference in stereopsis between the 2 treatment groups: Frisby (contact lens, 6 [11%]; IOL, 7 [13%]; P = .99), Randot (contact lens, 3 [6%]; IOL, 1 [2%]; P = .62), or Titmus (contact lens, 8 [15%]; IOL, 13 [23%]; P = .34). The median age at surgery for patients with stereopsis was younger than for those without stereopsis (1.2 vs 2.4 months; P = .002). The median visual acuity for patients with stereopsis was better than for those without stereopsis (20/40 vs 20/252; P = .0003).

Conclusion: The type of optical correction did not influence stereopsis outcomes. However, 2 other factors did: age at surgery and visual acuity in the treated eye at age 4.5 years. Early surgery for unilateral congenital cataract and the presence of visual acuity better than or equal to 20/40 appear to be more important than the type of initial optical correction used for the development of stereopsis.

Trial registration: ClinicalTrials.gov NCT00212134.

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Figures

Figure 1
Figure 1
Data plots showing presence or absence of stereopsis vs. age at cataract surgery (months) or visual acuity at age 4.5 years in the Infant Aphakia Treatment Study. Top Panel: Individual value plot comparing age at cataract surgery with presence or absence of stereopsis at age 4.5 years. Bottom Panel: Individual value plot comparing recognition visual acuity for the treated eye with the presence or absence of stereopsis at age 4.5 years.
Figure 1
Figure 1
Data plots showing presence or absence of stereopsis vs. age at cataract surgery (months) or visual acuity at age 4.5 years in the Infant Aphakia Treatment Study. Top Panel: Individual value plot comparing age at cataract surgery with presence or absence of stereopsis at age 4.5 years. Bottom Panel: Individual value plot comparing recognition visual acuity for the treated eye with the presence or absence of stereopsis at age 4.5 years.
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