Hepatitis C virus inhibitory hydrolysable tannins from the fruits of Terminalia chebula

Abstract

Two new hydrolysable tannins, chebumeinin A (1) and chebumeinin B (2), together with eight known related compounds (3-10), were isolated from the fruits of Terminalia chebula. The new compounds were structurally determined by analysis of their spectroscopic data and the known compounds characterized by comparing their spectroscopic data with literature values. All isolates were evaluated by an HCV protease inhibition assay, and some compounds were found to be potently active.

Keywords: 5-O-galloylshikimic acid (PubChem CID: 460899); Chebulagic acid (PubChem CID: 442674); Chebulic acid (PubChem CID: 71308174); Chebumeinin; Chebumeinin A, chebumeinin B Casuarinin (PubChem CID: 157395); Corilagin (PubChem CID: 73568); Ellagic acid (PubChem CID: 5281855); Gallic acid (PubChem CID: 370); HCV protease inhibition; Hydrolysable tannins; Pentagalloyl glucose (PubChem CID: 65238); Small molecule HCV-protease inhibitors; Terminalia chebula.