Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2014 Nov;159(2-3):421-5.
doi: 10.1016/j.schres.2014.09.018. Epub 2014 Sep 26.

Treatment response to the RENEW weight loss intervention in schizophrenia: impact of intervention setting

Catana Brown  1 , Jeannine Goetz  2 , Edna Hamera  3 , Byron Gajewski  2
Affiliations
Randomized Controlled Trial

Treatment response to the RENEW weight loss intervention in schizophrenia: impact of intervention setting

Catana Brown et al. Schizophr Res. 2014 Nov.

Abstract

Background: Individuals with serious mental illness have high rates of obesity and a need for specialized weight loss intervention programs. This study examines the efficacy of the RENEW weight loss intervention and examines the impact of the intervention setting on outcomes.

Method: 136 individuals with serious mental illness from 4 different settings were randomly assigned to receive the RENEW weight loss intervention or a control condition of treatment as usual. The RENEW intervention is a one year program that includes an intensive, maintenance and intermittent supports phase.

Results: The intervention group experienced a modest weight loss of 4.8 lbs at 3 months, 4.1 lbs at 6 months and a slight weight gain of 1.5 lbs at 12 months. The control group gained a total of 6.2 lbs at 12 months. However when settings were examined separately the responder sites had a weight loss of 9.4 lbs at 3 months, 10.9 lbs at 6 months and 7 lbs at 12 months.

Discussion: These results suggest that the settings in which individuals receive services may act as a support or hindrance toward response to weight loss interventions. The concept of the obesogenic environment deserves further examination as a factor in the success of weight loss programs.

Keywords: Intervention; Obesity; Schizophrenia; Weight loss.

PubMed Disclaimer

Conflict of interest statement

Conflict of interest

There were no conflicts of interest.

Figures

Figure 1
Figure 1
Weight change by site for the intervention groups
Figure 2
Figure 2
Weight loss responders (Sites 1 and 3) vs non-responders (Sites 2 and 4) in the Intervention group
See this image and copyright information in PMC

References

    1. Allison DB, Mentore JL, Heo M. Antipsychotic-induced weight gain: a comprehensive research synthesis. Am J Psychiatry. 1999;156(11):1686–1696. - PubMed
    1. Allison DB, Newcomer JW, Dunn AL, Blumenthal JA, Fabricatore AN, Daumit GL, Cope MB, Riley WT, Vreeland B, Hibbeln JR, Alpert JE. Obesity among those with mental disorders: a National Institute of Mental Health meeting report. Am J Prev Med. 2009;36(4):341–350. - PubMed
    1. Bartels S, Desilets R. Health promotion programs for people with serious mental illness (Prepared by the Dartmouth Health Promotion Research Team) SAMHSA-HRSA Center for Integrated Health Solutions; Washington, D.C: 2012.
    1. Brown C, Goetz J, Hamera E. Weight loss intervention for people with serious mental illness: A randomized controlled trial of the RENEW program. Psychiatr Serv. 2011;62(7):800–803. - PMC - PubMed
    1. Casey DE, Haupt DW, Newcomer JW, Henderson DC, Sernyak MJ, Davidson M, Lindenmayer JP, Manoukian SV, Banerji MA, Lebovitz HE, Hennekens CH. Antipsychotic-induced weight gain and metabolic abnormalities: implications for increased mortality in patients with schizophrenia. J Clin Psychiatry. 2004;65(Suppl 7):4–18. - PubMed

Publication types

Substances