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Randomized Controlled Trial
. 2014 Nov;106(2):228-35.
doi: 10.1016/j.diabres.2014.08.021. Epub 2014 Sep 6.

Epicardial adipose tissue volume as a marker of coronary artery disease severity in patients with diabetes independent of coronary artery calcium: findings from the CTRAD study

Dilbahar S Mohar  1 , Jonathan Salcedo  1 , Khiet C Hoang  1 , Shivesh Kumar  1 , Farhood Saremi  2 , Ashwini S Erande  1 , Nassim Naderi  1 , Pradeep Nadeswaran  1 , Christine Le  2 , Shaista Malik  3
Affiliations
Randomized Controlled Trial

Epicardial adipose tissue volume as a marker of coronary artery disease severity in patients with diabetes independent of coronary artery calcium: findings from the CTRAD study

Dilbahar S Mohar et al. Diabetes Res Clin Pract. 2014 Nov.

Abstract

Aims: The association between epicardial adipose tissue (EAT) volume and coronary artery disease (CAD) severity was evaluated, independent of traditional risk factors and coronary artery calcium (CAC) scores, in patients with diabetes type 2 (DM-2) using cardiac computed tomography angiography (CTA).

Methods: A multivariate analysis was utilized to assess for an independent association after calculating EAT volume, CAD severity, and calcium scores in 92 patients with DM-II from the CTRAD study. We graded CAD severity as none (normal coronaries), mild-moderate (<70% stenosis), and severe (70% or greater stenosis).

Results: A total of 39 (42.3%) asymptomatic patients with diabetes did not have CAD; 30.4% had mild/moderate CAD; and 27.1% had severe CAD. Mean EAT volume was highest in patients with severe CAD (143.14 cm(3)) as compared to mild/moderate CAD (112.7 cm(3)), and no CAD (107.5 cm(3)) (p = 0.003). After adjustment of clinical risk factors, notably, CAC score, multivariate regression analysis showed EAT volume was an independent predictor of CAD severity in this sample (odds ratio 11.2, 95% confidence interval 1.7-73.8, p = 0.01).

Conclusions: Increasing EAT volume in asymptomatic patients with DM-II is associated with presence of severe CAD, independent of BMI and CAC, as well as traditional risk factors.

Keywords: Computed tomography angiography; Coronary artery disease; Diabetes; EAT; Multi-detector computed tomography; NCT01564485; Pericardial fat.

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Conflict of interest statement

Disclosures: The authors declare that they have no conflict of interest

Figures

Figure 1
Figure 1
Epicardial adipose tissue (EAT) total volume measurement. Segmentation of EAT was achieved by isolating the EAT by manually tracing the pericardium in the axial view. After segmentation, a threshold of −190 to −30 Hounsfield units was applied to isolate the adipose tissue. (A) EAT in someone with higher volume (B) EAT in someone with lower volume
Figure 1
Figure 1
Epicardial adipose tissue (EAT) total volume measurement. Segmentation of EAT was achieved by isolating the EAT by manually tracing the pericardium in the axial view. After segmentation, a threshold of −190 to −30 Hounsfield units was applied to isolate the adipose tissue. (A) EAT in someone with higher volume (B) EAT in someone with lower volume
See this image and copyright information in PMC

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