Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2015 Apr;47(1-2):101-10.
doi: 10.1007/s10863-014-9574-8. Epub 2014 Sep 28.

Signaling pathways leading to ischemic mitochondrial neuroprotection

John W Thompson  1 , Srinivasan V Narayanan, Kevin B Koronowski, Kahlilia Morris-Blanco, Kunjan R Dave, Miguel A Perez-Pinzon
Affiliations
Review

Signaling pathways leading to ischemic mitochondrial neuroprotection

John W Thompson et al. J Bioenerg Biomembr. 2015 Apr.

Abstract

There is extensive evidence that ischemic/reperfusion mediated mitochondrial dysfunction is a major contributor to ischemic damage. However data also indicates that mild ischemic stress induces mitochondrial dependent activation of ischemic preconditioning. Ischemic preconditioning is a neuroprotective mechanism which is activated upon a brief sub-injurious ischemic exposure and is sufficient to provide protection against a subsequent lethal ischemic insult. Current research demonstrates that mitochondria are not only the inducers of but are also an important target of ischemic preconditioning mediated protection. Numerous proteins and signaling pathways are activated by ischemic preconditioning which protect the mitochondria against ischemic damage. In this review we examine some of the proteins activated by ischemic precondition which counteracts the deleterious effects of ischemia/reperfusion thereby maintaining normal mitochondrial activity and lead to ischemic tolerance.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Ischemic preconditioning (IPC) activates numerous signaling pathways which act in concert to protect the mitochondria against the deleterious effects of ischemia/reperfusion
See this image and copyright information in PMC

References

    1. Alan L, Smolkova K, Kronusova E, Santorova J, Jezek P. Absolute levels of transcripts for mitochondrial uncoupling proteins UCP2, UCP3, UCP4, and UCP5 show different patterns in rat and mice tissues. J Bioenerg Biomembr. 2009;41:71–78. - PubMed
    1. Alano CC, Tran A, Tao R, Ying W, Karliner JS, et al. Differences among cell types in NAD(+) compartmentalization: a comparison of neurons, astrocytes, and cardiac myocytes. J Neurosci Res. 2007;85:3378–3385. - PubMed
    1. Ali YO, Ruan K, Zhai RG. NMNAT suppresses tau-induced neurodegeneration by promoting clearance of hyperphosphorylated tau oligomers in a Drosophila model of tauopathy. Hum Mol Genet. 2012;21:237–250. - PMC - PubMed
    1. Andrews ZB, Diano S, Horvath TL. Mitochondrial uncoupling proteins in the CNS: in support of function and survival. Nat Rev Neurosci. 2005;6:829–840. - PubMed
    1. Aquilano K, Vigilanza P, Baldelli S, Pagliei B, Rotilio G, et al. Peroxisome proliferator-activated receptor gamma co-activator 1alpha (PGC-1alpha) and sirtuin 1 (SIRT1) reside in mitochondria: possible direct function in mitochondrial biogenesis. J Biol Chem. 2010;285:21590–21599. - PMC - PubMed

Publication types

LinkOut - more resources