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. 2014 Sep 10;28(14):2160-2.
doi: 10.1097/QAD.0000000000000373.

HIV-2 X4 tropism is associated with lower CD4+ cell count in treatment-experienced patients

Benoit Visseaux  1 , Charlotte Charpentier, Caroline Rouard, Catherine Fagard, David Glohi, Roland Tubiana, Florence Damond, Françoise Brun-Vézinet, Sophie Matheron, Diane Descamps; French HIV-2 ANRS Cohort CO5
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HIV-2 X4 tropism is associated with lower CD4+ cell count in treatment-experienced patients

Benoit Visseaux et al. AIDS. .

Abstract

The distribution and evolution of X4/R5 viral tropism during HIV-2 infection remains unknown. HIV-2 tropism was assessed in 83 antiretroviral-experienced patients with virological failure. Tropism was predicted as X4 in 58% of patients and was associated with a CD4 cell count of less than 100 cells/μl, and with a higher number of drug resistance mutations. This high prevalence of X4 virus might compromise the use of CCR5 inhibitors, currently mostly considered in HIV-2 salvage therapy of highly pretreated patients.

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