Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2014 May-Jun;34(3):250-3.
doi: 10.5144/0256-4947.2014.250.

Kounis syndrome: acute inferior myocardial infarction with atroventricular node block due to ceftriaxone: a first reported case

Akram Abdeljaber Saleh  1
Affiliations
Case Reports

Kounis syndrome: acute inferior myocardial infarction with atroventricular node block due to ceftriaxone: a first reported case

Akram Abdeljaber Saleh. Ann Saudi Med. 2014 May-Jun.

Abstract

Cefriaxone is a third-generation cephalosporin that might rarely cause a severe allergic reaction. Acute cardiac emergencies are quite rare in the setting of drug allergies. Here, we report the first case of myocardial infarction and AV-block after intravenous cefriaxone administration.

PubMed Disclaimer

Conflict of interest statement

Conflict of interest

Non-declared.

Figures

Figure 1
Figure 1
12-lead ECG shows ST-segment elevation in leads 11.111 and aVF with 2:1 AV-block.
Figure 2
Figure 2
Right coronary angiogram shows multiple tight stenotic segments.
Figure 3
Figure 3
Right coronary angiogram after intracoronary nitrate.
Figure 4
Figure 4
ECG revealed normal sinus rhythm with no AV-block.
See this image and copyright information in PMC

Comment in

  • Kounis syndrome and antibiotics.
    Biteker FS, Dogan V, Mert KU, Mert GO, Biteker M. Biteker FS, et al. Ann Saudi Med. 2014 Nov-Dec;34(6):556. doi: 10.5144/0256-4947.2014.556. Ann Saudi Med. 2014. PMID: 25971835 Free PMC article. No abstract available.

References

    1. Norrby SR. Side effects of cephalosporins. Drugs. 1987;34(supp 2):105. - PubMed
    1. Kelkar PS, Li JT. Cephalosporin allergy. N Engl J Med. 2001;354:804. - PubMed
    1. Kounis NG, Zavras GM. Histamine-induced coronary artery spasm: the concept of allergic angina. Br J Clin Pract. 1991;45:121–128. - PubMed
    1. Biteker M. Current understanding of Kounis syndrome. Expert Rev Clin Immunol. 2010;6:1–12. - PubMed
    1. Kounis NG. Kounis syndrome (allergic angina and allergic myocardial infarction): a natural paradigm? Int J Cardiol. 2006;110:7–16. - PubMed

Publication types

MeSH terms

LinkOut - more resources