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Review
. 1989 Jan;10(1):17-23.
doi: 10.1016/0167-5699(89)90060-1.

Antigen-presenting cells for unprimed T cells

J Sprent, M Schaefer
Review

Antigen-presenting cells for unprimed T cells

J Sprent et al. Immunol Today. 1989 Jan.

Abstract

The triggering requirements of T cells differ for primed and unprimed cells: primed T cells can be triggered to produce lymphokines without viable antigen-presenting cells (APCs), apparently by crosslinking the T-cell receptor (TCR). Unprimed T cells do, however, require viable APCs and here Jonathan Sprent and Mary Schaefer review what type of cells can carry out this function, with particular reference to APCs for unprimed CD8+ cells.

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