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. 2014 Nov 21;12(43):8775-82.
doi: 10.1039/c4ob01832j.

Robust asymmetric synthesis of unnatural alkenyl amino acids for conformationally constrained α-helix peptides

Boris Aillard  1 , Naomi S Robertson, Adam R Baldwin, Siobhan Robins, Andrew G Jamieson
Affiliations

Robust asymmetric synthesis of unnatural alkenyl amino acids for conformationally constrained α-helix peptides

Boris Aillard et al. Org Biomol Chem. .

Abstract

The efficient asymmetric synthesis of unnatural alkenyl amino acids required for peptide 'stapling' has been achieved using alkylation of a fluorine-modified Ni(II) Schiff base complex as the key step.

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