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Comment
. 2014 Sep 29;30(6):641-2.
doi: 10.1016/j.devcel.2014.09.003.

Worming toward transdifferentiation, one (Epigenetic) step at a time

Ergin Beyret  1 , Juan Carlos Izpisua Belmonte  2
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Comment

Worming toward transdifferentiation, one (Epigenetic) step at a time

Ergin Beyret et al. Dev Cell. .
Free article

Abstract

Manipulation of cellular identity in the laboratory is generally inefficient due to stochastic events, including epigenomic alterations. Recently in Science, Zuryn et al. (2014) demonstrate that the efficiency of a naturally occurring transdifferentiation event in Caenorhabditis elegans is ensured through stepwise epigenetic modifications during specific phases of lineage conversion.

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