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. 1989 Jul 31;162(2):852-6.
doi: 10.1016/0006-291x(89)92388-7.

Inositol trisphosphate induces calcium release from Neurospora crassa vacuoles

G Cornelius  1 , G Gebauer, D Techel
Affiliations

Inositol trisphosphate induces calcium release from Neurospora crassa vacuoles

G Cornelius et al. Biochem Biophys Res Commun. .

Abstract

Inositol 1,4,5-trisphosphate is known to release calcium ions from intracellular stores thought to be parts of endoplasmic reticulum in animal cells. In Neurospora crassa, however, inositol 1,4,5-trisphosphate acts on vacuoles stimulating a calcium efflux with a Km of 5.28 microM. The calcium release is inhibited effectively by dantrolene. These results were obtained by applying two independent methods, measuring calcium binding to fura-2 and loading vacuoles with 45Ca.

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