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Comment
. 2015 Jun;138(Pt 6):e354.
doi: 10.1093/brain/awu275. Epub 2014 Sep 29.

The first step in modern lesion-deficit analysis

Parashkev Nachev  1
Affiliations
Comment

The first step in modern lesion-deficit analysis

Parashkev Nachev. Brain. 2015 Jun.
No abstract available

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Figures

Figure 1
Figure 1
(A) Illustration of how stereotyped patterns of brain damage (schematized in grey) across a set of patients can hypothetically mislocalize damage of any part of critical area A (in dotted lines) to the non-critical area B (in dotted lines). This will happen whenever the spatial variability of damage to a non-critical area is less for the group or factor of interest than for the critical area. Such stereotypy of damage—a hidden deep structure in the data—may occur where the lesions follow a consistent non-neural architecture, as is the case with vascular lesions. (B) Illustration of exactly the same scenario, but now seen through the prism of a large scale discretization into five regions of interest (ROIs), with the colour map indicating the significance of the association with the putative symptom (the more red the stronger). Note that the problem is not only not solved, it is now rendered insoluble by multivariate methods because the biasing effects are concealed within the regions of interest.
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References

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