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Review
. 2015 Jan;165(1-2):23-7.
doi: 10.1007/s10354-014-0313-x. Epub 2014 Oct 1.

Blockade of co-stimulation in chronic inflammatory diseases

Clemens Scheinecker  1
Affiliations
Review

Blockade of co-stimulation in chronic inflammatory diseases

Clemens Scheinecker. Wien Med Wochenschr. 2015 Jan.

Abstract

Costimulatory molecules are key elements in T cell activation. Therapeutic inhibition of costimulatory pathways have been recognized as valid therapeutic strategies in the treatment of various inflammatory diseases. This article will describe their mechanisms of action and will summarize the results from clinical trials in the field of rheumatologic diseases.

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