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. 2014 Oct 1;190(7):837-9.
doi: 10.1164/rccm.201405-0993LE.

Phrenic nerve stimulation increases human diaphragm fiber force after cardiothoracic surgery

Bumsoo Ahn  1 , Thomas Beaver, Tomas Martin, Philip Hess, Babette A Brumback, Shakeel Ahmed, Barbara K Smith, Christiaan Leeuwenburgh, A Daniel Martin, Leonardo F Ferreira
Affiliations

Phrenic nerve stimulation increases human diaphragm fiber force after cardiothoracic surgery

Bumsoo Ahn et al. Am J Respir Crit Care Med. .
No abstract available

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Figures

Figure 1.
Figure 1.
Phrenic nerve stimulation increases diaphragm fiber force after cardiothoracic surgery. (A) Specific force versus pCa relationship for all fibers from control and stimulated hemidiaphragms. Specific force is absolute force (in kilonewtons) normalized to the fiber cross-sectional area (in meters squared). pCa is the negative log[Ca2+], and in the figure shown, [Ca2+] ranges from 0.1 to 32 μM. Symbols and error bars are mean ± standard deviation. Solid and dashed lines are best fit from Hill equation. (B) Maximal calcium-activated (pCa 4.5) specific force. (C) pCa50 is pCa that elicits 50% maximal force and represents calcium sensitivity of the contractile apparatus. (D) Hill coefficient is equivalent to the slope of force–pCa relationship and represents the cooperativity of thin-filament activation. (E) Rate constant of tension redevelopment (ktr) obtained from quick-release and restretch test. The ktr is an indicator of cross-bridge cycling kinetics. (B–E) Data are for each individual fiber studied (symbols) and mean for condition (solid line). The four unique symbols shown represent fibers from each patient. *P < 0.05 determined by linear mixed model as detailed in the text.
See this image and copyright information in PMC

References

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