Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014 Oct 1;190(7):837-9.
doi: 10.1164/rccm.201405-0993LE.

Phrenic nerve stimulation increases human diaphragm fiber force after cardiothoracic surgery

Bumsoo Ahn  1 , Thomas Beaver, Tomas Martin, Philip Hess, Babette A Brumback, Shakeel Ahmed, Barbara K Smith, Christiaan Leeuwenburgh, A Daniel Martin, Leonardo F Ferreira
Affiliations

Phrenic nerve stimulation increases human diaphragm fiber force after cardiothoracic surgery

Bumsoo Ahn et al. Am J Respir Crit Care Med. .
No abstract available

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Phrenic nerve stimulation increases diaphragm fiber force after cardiothoracic surgery. (A) Specific force versus pCa relationship for all fibers from control and stimulated hemidiaphragms. Specific force is absolute force (in kilonewtons) normalized to the fiber cross-sectional area (in meters squared). pCa is the negative log[Ca2+], and in the figure shown, [Ca2+] ranges from 0.1 to 32 μM. Symbols and error bars are mean ± standard deviation. Solid and dashed lines are best fit from Hill equation. (B) Maximal calcium-activated (pCa 4.5) specific force. (C) pCa50 is pCa that elicits 50% maximal force and represents calcium sensitivity of the contractile apparatus. (D) Hill coefficient is equivalent to the slope of force–pCa relationship and represents the cooperativity of thin-filament activation. (E) Rate constant of tension redevelopment (ktr) obtained from quick-release and restretch test. The ktr is an indicator of cross-bridge cycling kinetics. (B–E) Data are for each individual fiber studied (symbols) and mean for condition (solid line). The four unique symbols shown represent fibers from each patient. *P < 0.05 determined by linear mixed model as detailed in the text.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Jaber S, Petrof BJ, Jung B, Chanques G, Berthet JP, Rabuel C, Bouyabrine H, Courouble P, Koechlin-Ramonatxo C, Sebbane M, et al. Rapidly progressive diaphragmatic weakness and injury during mechanical ventilation in humans. Am J Respir Crit Care Med. 2011;183:364–371. - PubMed
    1. Welvaart WN, Paul MA, Stienen GJ, van Hees HW, Loer SA, Bouwman R, Niessen H, de Man FS, Witt CC, Granzier H, et al. Selective diaphragm muscle weakness after contractile inactivity during thoracic surgery. Ann Surg. 2011;254:1044–1049. - PubMed
    1. Powers SK, Wiggs MP, Sollanek KJ, Smuder AJ. Ventilator-induced diaphragm dysfunction: cause and effect. Am J Physiol Regul Integr Comp Physiol. 2013;305:R464–R477. - PubMed
    1. Masmoudi H, Coirault C, Demoule A, Mayaux J, Beuvin M, Romero N, Assouad J, Similowski T. Can phrenic stimulation protect the diaphragm from mechanical ventilation-induced damage? Eur Respir J. 2013;42:280–283. - PubMed
    1. Martin AD, Joseph AM, Beaver TM, Smith BK, Martin TD, Berg K, Hess PJ, Deoghare HV, Leeuwenburgh C. Effect of intermittent phrenic nerve stimulation during cardiothoracic surgery on mitochondrial respiration in the human diaphragm. Crit Care Med. 2014;42:e152–e156. - PMC - PubMed