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Comparative Study
. 2014 Oct 2:11:51.
doi: 10.1186/s12989-014-0051-7.

Air pollution exposure and lung function in highly exposed subjects in Beijing, China: a repeated-measure study

Andrea A Baccarelli  1 , Yinan Zheng  2 , Xiao Zhang  3 , Dou Chang  4 , Lei Liu  5 , Katherine Rose Wolf  6 , Zhou Zhang  7 , John P McCracken  8 , Anaité Díaz  9 , Pier Alberto Bertazzi  10 , Joel Schwartz  11 , Sheng Wang  12 , Choong-Min Kang  13 , Petros Koutrakis  14 , Lifang Hou  15   16
Affiliations
Comparative Study

Air pollution exposure and lung function in highly exposed subjects in Beijing, China: a repeated-measure study

Andrea A Baccarelli et al. Part Fibre Toxicol. .

Abstract

Background: Exposure to ambient particulate matter (PM) has been associated with reduced lung function. Elemental components of PM have been suggested to have critical roles in PM toxicity, but their contribution to respiratory effects remains under-investigated. We evaluated the effects of traffic-related PM(2.5) and its elemental components on lung function in two highly exposed groups of healthy adults in Beijing, China.

Methods: The Beijing Truck Driver Air Pollution Study (BTDAS) included 60 truck drivers and 60 office workers evaluated in 2008. On two days separated by 1-2 weeks, we measured lung function at the end of the work day, personal PM(2.5), and nine elemental components of PM(2.5) during eight hours of work, i.e., elemental carbon (EC), potassium (K), sulfur (S), iron (Fe), silicon (Si), aluminum (Al), zinc (Zn), calcium (Ca), and titanium (Ti). We used covariate-adjusted mixed-effects models including PM(2.5) as a covariate to estimate the percentage change in lung function associated with an inter-quartile range (IQR) exposure increase.

Results: The two groups had high and overlapping exposure distributions with mean personal PM(2.5) of 94.6 μg/m³ (IQR: 48.5-126.6) in office workers and 126.8 μg/m³ (IQR: 73.9-160.5) in truck drivers. The distributions of the nine elements showed group-specific profiles and generally higher levels in truck drivers. In all subjects combined, forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC) did not significantly correlate with PM(2.5). However, FEV1 showed negative associations with concentrations of four elements: Si (-3.07%, 95% CI: -5.00; -1.11, IQR: 1.54), Al (-2.88%, 95% CI: -4.91; -0.81, IQR: 0.86), Ca (-1.86%, 95% CI: -2.95; -0.76, IQR: 1.33), and Ti (-2.58%, 95% CI: -4.44; -0.68, IQR: 0.03), and FVC showed negative associations with concentrations of three elements: Si (-3.23%, 95% CI: -5.61; -0.79), Al (-3.26%, 95% CI: -5.73; -0.72), and Ca (-1.86%, 95% CI: -3.23; -0.47). In stratified analysis, Si, Al, Ca, and Ti showed associations with lung function only among truck drivers, and no significant association among office workers.

Conclusion: Selected elemental components of PM(2.5) showed effects on lung function that were not found in analyses of particle levels alone.

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References

    1. Biggeri A, Bellini P, Terracini B. [Meta-analysis of the Italian studies on short-term effects of air pollution–MISA 1996–2002] Epidemiol Prev. 2004;28:4–100. - PubMed
    1. Katsouyanni K, Touloumi G, Samoli E, Gryparis A, Le Tertre A, Monopolis Y, Rossi G, Zmirou D, Ballester F, Boumghar A, Anderson HR, Wojtyniak B, Paldy A, Braunstein R, Pekkanen J, Schindler C, Schwartz J. Confounding and effect modification in the short-term effects of ambient particles on total mortality: results from 29 European cities within the APHEA2 project. Epidemiology. 2001;12:521–531. doi: 10.1097/00001648-200109000-00011. - DOI - PubMed
    1. Atkinson RW, Anderson HR, Sunyer J, Ayres J, Baccini M, Vonk JM, Boumghar A, Forastiere F, Forsberg B, Touloumi G, Schwartz J, Katsouyanni K. Acute effects of particulate air pollution on respiratory admissions: results from APHEA 2 project. Air Pollution and Health: a European Approach. Am J Respir Crit Care Med. 2001;164:1860–1866. doi: 10.1164/ajrccm.164.10.2010138. - DOI - PubMed
    1. Weinmayr G, Romeo E, De Sario M, Weiland SK, Forastiere F. Short-term effects of PM10 and NO2 on respiratory health among children with asthma or asthma-like symptoms: a systematic review and meta-analysis. Environ Health Perspect. 2010;118:449–457. doi: 10.1289/ehp.0900844. - DOI - PMC - PubMed
    1. Rice MB, Ljungman PL, Wilker EH, Gold DR, Schwartz JD, Koutrakis P, Washko GR, O’Connor GT, Mittleman MA. Short-term exposure to air pollution and lung function in the Framingham Heart Study. Am J Respir Crit Care Med. 2013;188:1351–1357. doi: 10.1164/rccm.201308-1414OC. - DOI - PMC - PubMed

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