Review
doi: 10.1016/0968-0004(89)90029-7.
The human T-cell receptor gamma (TRG) genes
- PMID: 2527426
- DOI: 10.1016/0968-0004(89)90029-7
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Review
The human T-cell receptor gamma (TRG) genes
Trends Biochem Sci.
1989 Jun.
Abstract
The human T-cell receptor gamma (TRG) chain genes, like those encoding the T-cell receptor alpha- and beta-polypeptides, undergo rearrangements specifically in T cells. The human TRG locus, which has been completely mapped, is composed of two constant region genes (TRGC), five joining segments (TRGJ) and at least 14 variable gamma-genes (TRGV). Eight variable genes are functional and belong to four different subgroups. The product of the rearranged TRG gene is the gamma-chain which is expressed, along with the delta-chain, at the surface of a subset of T lymphocytes. Although some gamma delta + cells display a cytolytic activity, their precise function remains to be elucidated.
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