Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2014 Oct 2:7:72.
doi: 10.1186/s13045-014-0072-6.

T cell immune abnormalities in immune thrombocytopenia

Xuebin Ji  1 , Liping Zhang  2 , Jun Peng  3 , Ming Hou  4
Affiliations
Review

T cell immune abnormalities in immune thrombocytopenia

Xuebin Ji et al. J Hematol Oncol. .

Abstract

Immune thrombocytopenia is an autoimmune disease with abnormal T cell immunity. Cytotoxic T cells, abnormal T regulatory cells, helper T cell imbalance, megakaryocyte maturation abnormalities and abnormal T cell anergy are involved in the pathogenesis of this condition. The loss of T cell-mediated immune tolerance to platelet auto-antigens plays a crucial role in immune thrombocytopenia. The induction of T cell tolerance is an important mechanism by which the pathogenesis and treatment of immune thrombocytopenia can be studied. Studies regarding the roles of the new inducible costimulator signal transduction pathway, the ubiquitin proteasome pathway, and the nuclear factor kappa B signal transduction pathway in the induction of T cell tolerance can help improve our understanding of immune theory and may provide a new theoretical basis for studying the pathogenesis and treatment of immune thrombocytopenia.

PubMed Disclaimer

Figures

Figure 1
Figure 1
T cell immune abnormalities in ITP pathogenesis. Immune thrombocytopenia pathogenesis is a complicated process. T cell immune abnormalities are involved in ITP pathogenesis. These abnormalities include platelet auto-antigen reactive cytotoxic T cells, abnormal numbers and functions of T regulatory cells, loss of Th1/Th2 balance, megakaryocyte maturation abnormalities and abnormal T cell anergy.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Olsson B, Andersson PO, Jacobsson S, Carlsson L, Wadenvik A. Disturbed apoptosis of T-cells in patients with active idiopathic thrombocytopenic purpura. Thromb Haemost. 2005;93:139–144. - PubMed
    1. Zhang XL, Peng J, Sun JZ, Guo CS, Yu Y, Wang ZG, Chu XX, Hou M. Modulation of immune response with cytotoxic T-lymphocyte-associated antigen 4 immunoglobulin-induced anergic T cells in chronic idiopathic thrombocytopenic purpura. J Thromb Haemost. 2008;6:158–165. doi: 10.1111/j.1538-7836.2007.02804.x. - DOI - PubMed
    1. Zhang XL, Peng J, Sun JZ, Liu JJ, Guo CS, Wang ZG, Yu Y, Shi Y, Qin P, Li SG, Zhang LN, Hou M. De novo induction of platelet-specific CD4(+) CD25(+) regulatory T cells from CD4(+) CD25(−) cells in patients with idiopathic thrombocytopenic purpura. Blood. 2009;113:2568–2577. doi: 10.1182/blood-2008-03-148288. - DOI - PubMed
    1. Aslam R, Hu Y, Gebremeskel S, Segel GB, Speck ER, Guo L, Kim M, Ni H, Freedman J, Semple JW. Thymic retention of CD4 + CD25 + FoxP3+ T regulatory cells is associated with their peripheral deficiency and thrombocytopenia in a murine model of immune thrombocytopenia. Blood. 2012;120:2127–2132. doi: 10.1182/blood-2012-02-413526. - DOI - PubMed
    1. Shan NN, Ji XB, Wang X, Li Y, Liu X, Zhu XJ, Hou M. In vitro recovery of Th1/Th2 balance in PBMCs from patients with immune thrombocytopenia through the actions of IL-18BPa/Fc. Thromb Res. 2011;128:e119–e124. doi: 10.1016/j.thromres.2011.07.012. - DOI - PubMed

Publication types