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Comment
. 2014 Oct;4(10):1120-2.
doi: 10.1158/2159-8290.CD-14-0918.

Understanding and targeting alkylator resistance in glioblastoma

Wolfgang Wick  1 , Michael Platten  2
Affiliations
Comment

Understanding and targeting alkylator resistance in glioblastoma

Wolfgang Wick et al. Cancer Discov. 2014 Oct.

Abstract

Alkylating chemotherapy is the mainstay in the treatment of pediatric and adult glioblastoma despite primary and acquired resistance and scientific efforts to precisely define therapies for individual patients. A focus on non-MGMT-mediated temozolomide resistance for pediatric glioblastoma suggests options for new drug combinations.

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