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Comment
. 2014 Nov 3;33(21):2442-3.
doi: 10.15252/embj.201490101. Epub 2014 Oct 1.

DUBs counteract parkin for efficient mitophagy

Ivan Dikic  1 , Anja Bremm  1
Affiliations
Comment

DUBs counteract parkin for efficient mitophagy

Ivan Dikic et al. EMBO J. .

Abstract

The Parkinson's disease-associated ubiquitin E3 ligase parkin impacts various cellular processes including the autophagic clearance of defective mitochondria. In this issue of The EMBO Journal, Durcan et al (2014) reveal a novel control mechanism of parkin-mediated mitophagy via the selective removal of atypical K6-linked ubiquitin chains from parkin by the deubiquitinase USP8. Together with recent studies on USP15 and USP30, this establishes a functional role for deubiquitination in mitophagy regulation.

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Figures

Figure 1
Figure 1
The parkin-mediated clearance of depolarized and fragmented mitochondria by autophagy is regulated by the deubiquitinases USP8, USP15 and USP30
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References

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