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. 2014 Summer;13(3):873-9.

Synthesis of some novel chromenopyrimidine derivatives and evaluation of their biological activities

Akbar Mobinikhaledi  1 , Naser Foroughifar  2 , Tahere Mosleh  1 , Ahmad Hamta  3
Affiliations

Synthesis of some novel chromenopyrimidine derivatives and evaluation of their biological activities

Akbar Mobinikhaledi et al. Iran J Pharm Res. 2014 Summer.

Abstract

Pyrimidine nucleosides are constituents of fundamental structure of the cells. There has been considerable attentions in the chemistry of pyrimidine derivatives due to having a wide range of biological activities such as antiviral, anti-malarial agents, cytostatic, antithelemintic, antibacterial, adenosine receptor ligands, anti-cancer agents, compounds targeting delayed-type hypersensivity and anti-convulsant agents. As a part of our research work in the synthesis of pyrimidines containing biological activities, a series of chromenopyrimidine derivatives were synthesized by reaction of an intermediate imine and ammonia derivatives in good to high yields. All synthesized compounds were characterized using IR and NMR ((1)H and (13)C) spectroscopy and elemental analysis data. The antibacterial activity of these compounds was investigated against Staphylococcus aureus (RTCC, 1885), and Escherichia Coli (ATCC, 35922).

Keywords: Antibacterial; Chromenopyrimidine; Imine; Multicomponent; Pyranopyrimidine.

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Figures

Scheme 1
Scheme 1
Synthetic pathway of compounds 6-8.
Scheme 2
Scheme 2
Synthetic pathway of compounds 9-20.
See this image and copyright information in PMC

References

    1. Lagoja I M. Pyrimidine as constituent of natural biologically active compounds. Chem. Biochem. 2005;2:1–50. - PubMed
    1. Hurst EW, Hull RTJ. Two new synthetic substances active against viruses of the psittacosis-lymphogranulomatrachoma group. Med. Pharm. Chem. 1961;3:215–229. - PubMed
    1. Machon Z, Cieplik J. Synthesis of furo[3,4-d]pyrimidine derivatives via reaction of 4-methylpyrimidine-5-carboxylic acids with thionyl chloride. Synt. 1986;2:142–144.
    1. Machon Z, Cieplik J. Synthesis and antineoplastic effects of furo[3,4-d]pyrimidine derivatives. J. Pharmacol. Pharm. 1988;40:201–208. - PubMed
    1. Mohamed NR, El-Saidi MM, Ali YM, Elnagdi MH. Utility of 6-amino-2-thiouracil as a precursor for the synthesis of bioactive pyrimidine derivatives. Bioorg. Med. Chem. 2007;15:6227–6235. - PubMed

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