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. 2014 Summer;13(3):1003-9.

A Randomized Clinical Trial Study: Anti-Oxidant, Anti-hyperglycemic and Anti-Hyperlipidemic Effects of Olibanum Gum in Type 2 Diabetic Patients

Abbas Azadmehr  1 , Amir Ziaee  2 , Laleh Ghanei  2 , Hassan Fallah Huseini  3 , Reza Hajiaghaee  4 , Bahareh Tavakoli-Far  5 , Gholamreza Kordafshari  6
Affiliations

A Randomized Clinical Trial Study: Anti-Oxidant, Anti-hyperglycemic and Anti-Hyperlipidemic Effects of Olibanum Gum in Type 2 Diabetic Patients

Abbas Azadmehr et al. Iran J Pharm Res. 2014 Summer.

Abstract

Diabetes is a common metabolic disease in the world that has many adverse effects. Olibanum gum resin (from trees of the genus Boswellia) has traditionally been used in the treatment of various diseases such as diabetes. The aim of this study was the comparison of Olibanum gum resin effect with placebo on the treatment of type 2 diabetes. Inclusion criteria was diabetic patients with fasting blood sugar (FBS) =140-200 mg/dL. This study has been designed as double-blined clinical trial on 71 patients with type 2 diabetes and the patients randomly were divided to interventional and placebo groups. The patients on standard anti-diabetic therapy (metformin) treated with Olibanum gum resin (400 mg caps) and placebo tow times per day for 12 weeks, respectively. At the end of the twelfth week, the FBS, HbA1c, Insulin, total Cholesterol (Chol), LDL, Triglyceride (TG), HDL and other parameters were measured. The Olibanum gum resin lowered the FBS, HbA1c, Insulin, Chol, LDL and TG levels significantly (p < 0.001, p < 0.001, p <0.001, p = 0.003, p < 0.001 and p < 0.001, respectively) without any significant effects on the other blood lipid levels and liver/kidney function tests (p > 0.05) compared with the placebo at the endpoint. Moreover, this plant showed anti-oxidant effect and also no adverse effects were reported. The results suggest that Olibanum gum resin could be used as a safe anti-oxidant, anti-hyperglycemic and anti-hyperlipidemic agent for type 2 diabetic patients.

Keywords: Diabetes; Hyperglycemia; Hyperlipidemia; Olibanum gum resin; Patients.

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Figures

Figure 1
Figure 1
The consort flowchart describing the progress of the patients through the trial
Figure 2
Figure 2
Box plot of decreases (before intervention – after intervention) in the fasting blood sugar (FBS) levels (mg/dL) of the Olibanum gum resin and placebo groups.
Figure 3
Figure 3
Box plot of decreases (before intervention – after intervention) in the blood glycosylated hemoglobin (HbA1c) levels (percent) of the Olibanum gum resin and placebo groups.
Figure 4
Figure 4
Box plot of decreases (before intervention – after intervention) in the blood insulin hormone levels (UI/L) of the Olibanum gum resin and placebo groups
Figure 5
Figure 5
Box plot of decreases (before intervention – after intervention) in the blood total cholesterol (Chol) levels (mg/ dL) of the Olibanum gum resin and placebo groups
Figure 6
Figure 6
Box plot of decreases (before intervention – after intervention) in the blood triglyceride (TG) levels (mg/dL) of the Olibanum gum resin and placebo groups
Figure 7
Figure 7
Box plot of decreases (before intervention – after intervention) in the blood LDL levels (mg/dL) of the Olibanum gum resin and placebo groups
See this image and copyright information in PMC

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