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Review
. 2014 Sep;6(9):1319-28.
doi: 10.3978/j.issn.2072-1439.2014.07.15.

Cardiovascular, diabetes, and cancer strips: evidences, mechanisms, and classifications

Chun-Song Hu  1 , Qing-Hua Wu  1 , Da-Yi Hu  1
Affiliations
Review

Cardiovascular, diabetes, and cancer strips: evidences, mechanisms, and classifications

Chun-Song Hu et al. J Thorac Dis. 2014 Sep.

Abstract

Objectives: To report and name firstly that there are cardiovascular disease (CVD), diabetes mellitus (DM) and cancers (CDC) strips; and disclose their mechanisms, classifications, and clinical significances.

Study design: Narrative and systematic review study and interpretive analysis.

Data sources and study selection: to collect and present related evidences on CDC strips from evidence-based, open-access, both Chinese- and English-language literatures in recent 10 years on clinical trials from PubMed according to keywords "CVD, DM and cancers" as well as authors' extensive clinical experience with the treatment of more than fifty thousands of patients with CVD, diabetes and cancers over the past decades, and analyze their related mechanisms and categories which based on authors' previous works.

Data extraction: data were mainly extracted from 48 articles which are listed in the reference section of this review. Qualitative, quantitative and mixed data were included, narratively and systematically reviewed.

Results: With several conceptual and technical breakthrough, authors present related evidences on CDC strips, these are, CVD and DM, DM and cancers, cancers and CVD linked, respectively; And "Bad SEED" +/- "bad soil" theory or doctrine may explain this phenomenon due to "internal environmental injure, abnormal or unbalance" in human body resulting from the role of risk factors (RFs) related multi-pathways and multi-targets, which including organ & tissue (e.g., vascular-specific), cell and gene-based mechanisms. Their classifications include main strips/type B, and Branches/type A as showed by tables and figures in this article.

Conclusions: There are CDC strips and related mechanisms and classifications. CDC strips may help us to understand, prevent, and control related common non-communicable diseases (NCDs) as well as these high risk strips.

Keywords: Cardiovascular disease (CVD); cancer; diabetes; evidence; mechanisms.

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Figures

Figure 1
Figure 1
Mechanisms on CDC strips: “Bad SEED” +/- “bad soil” Theory or Doctrine, which involved organ & tissue (e.g., vascular-specific), cell and gene-based multi-pathways and multi-targets. Here, “Bad SEED” means abnormal E(e) SEED-BasED lifestyles which including related RFs; “bad soil” means related genetic RFs, such as family history, gene mutation, etc. These lead to “internal environment injure, abnormal or unbalance”, and finally to CDC strips. RFs, risk factors.
Figure 2
Figure 2
(A) There are three pairs of branches (type A) in CDC strips, which including Cv-DM or DM-Cv, Ca-Cv or Cv-Ca, and Ca-DM or DM-Ca, according to the onset time of each disease; (B) there are six main strips (type B), which including Cv-DM-Ca, Ca-DM-Cv, DM-Cv-Ca, DM-Ca-Cv, Cv-Ca-DM, Ca-Cv-DM, according to the onset time of each disease.
See this image and copyright information in PMC

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