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. 2014 Oct;5(4):167-71.
doi: 10.4103/2229-3485.140556.

Effect of vitamin D3 on mild to moderate persistent asthmatic patients: A randomized controlled pilot study

A D Nageswari  1 , M G Rajanandh  2 , R Kamala Priyanka  3 , P Rajasekhar  3
Affiliations

Effect of vitamin D3 on mild to moderate persistent asthmatic patients: A randomized controlled pilot study

A D Nageswari et al. Perspect Clin Res. 2014 Oct.

Abstract

Background: Asthma is a common chronic inflammatory disease of the bronchial airways. Well defined treatment options for asthma are very few. The role of vitamin D3 on asthma is still baffling.

Aim: We have examined the effect of vitamin D3 supplementation in mild to moderate persistent asthma patients.

Materials and methods: We conducted an open labeled, randomized comparative trial in 48 asthma patients. The study duration was about 90 days. The study had a run-in-period of 2 weeks. At the end of run-in-period, patients were divided into two groups: Usual care group (n = 31) patients received budesonide and formoterol and intervention care group (n = 32) patients received vitamin D3 supplementation along with their regular medicine.

Results: The primary outcome of the study was to measure the improvement in forced expiratory volume in 1 second (FEV1). Patients in both groups had a significant improvement in FEV1 at the end of the study. The mean difference in percentage predicted FEV1 in usual care and intervention care group was 4.95 and 7.07 respectively.

Conclusion: The study concluded that adjunctive therapy of vitamin D3 is effective in asthma patients. The present study will be an evidence based report; however, future studies are warranted in longer duration of time to substantiate the present findings.

Keywords: Asthma; budesonide; forced expiratory volume in 1 s; formoterol; vitamin D3.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Flow of patients and CONSORT Diagram
See this image and copyright information in PMC

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