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. 2013 Aug 31;2(3):245-54.
doi: 10.5681/jcs.2013.030. eCollection 2013 Sep.

Comparing the effect of mefenamic Acid and vitex agnus on intrauterine device induced bleeding

Parisa Yavarikia  1 , Mahnaz Shahnazi  1 , Samira Hadavand Mirzaie  1 , Yousef Javadzadeh  2 , Razieh Lutfi  3
Affiliations

Comparing the effect of mefenamic Acid and vitex agnus on intrauterine device induced bleeding

Parisa Yavarikia et al. J Caring Sci. .

Abstract

Introduction: Increased bleeding is the most common cause of intrauterine device (IUD) removal. The use of alternative therapies to treat bleeding has increased due to the complications of medications. But most alternative therapies are not accepted by women. Therefore, conducting studies to find the right treatment with fewer complications and being acceptable is necessary. This study aimed to compare the effect of mefenamic acid and vitex agnus castus on IUD induced bleeding.

Methods: This was a double blinded randomized controlled clinical trial. It was conducted on 84 women with random allocation in to two groups of 42 treated with mefenamic acid and vitex agnus capsules taking three times a day during menstruation for four months. Data were collected by demographic questionnaire and Higham 5 stage chart (1 month before the treatment and 4 months during the treatment)., Paired t-test, independent t-test, chi-square test, analysis of variance (ANOVA) with repeated measurements, and SPSS software were used to determine the results.

Results: Mefenamic acid and vitex agnus significantly decreased bleeding. This decrease in month 4 was 52% in the mefenamic acid group and 47.6% in the vitex agnus group. The mean bleeding score changes was statistically significant between the two groups in the first three months and before the intervention. In the mefenamic acid group, the decreased bleeding was significantly more than the vitex agnus group. However, during the 4(th) month, the mean change was not statistically significant.

Conclusion: Mefenamic acid and vitex agnus were both effective on IUD induced bleeding; however, mefenamic acid was more effective.

Keywords: Bleeding; Intrauterine device; Mefenamic acid; Vitex agnus castus.

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References

    1. Thonneau P, Goulard H, Goyaux N. Risk factors for intrauterine device failure: a review. Contraception. 2001;64(1):33–7. - PubMed
    1. Gharekhani P, Behjatnia B, Paydar M. The main protests and cure of diseases. Tehran: Esharat publication; 1993.
    1. O'Brien PA, Kulier R, Helmerhorst FM, Usher-Patel M, d'Arcangues C. Copper-containing, framed intrauterine devices for contraception: a systematic review of randomized controlled trials. Contraception. 2008;77(5):318-27. - PubMed
    1. Ali MM, Cleland J. Oral contraceptive discontinuation and its aftermath in 19 developing countries. Contraception. 2010;81(1):22–9. - PubMed
    1. Livingstone M, Fraser IS. Mechanisms of abnormal uterine bleeding. Human reproduction update. 2002;8(1):60–7. - PubMed

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