Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1989 May;8(5):1341-8.
doi: 10.1002/j.1460-2075.1989.tb03514.x.

Endocytosis and recycling of the fibronectin receptor in CHO cells

M S Bretscher  1
Affiliations

Endocytosis and recycling of the fibronectin receptor in CHO cells

M S Bretscher. EMBO J. 1989 May.

Erratum in

  • EMBO J 1989 Jul;8(7):2122

Abstract

An anti-fibronectin receptor monoclonal antibody preferentially labels the leading edges of freshly plated CHO fibroblasts, suggesting that this receptor circulates through the endocytic cycle. Using a new labelling reagent, I show that this receptor is indeed endocytosed at 37 degrees C and then returned to the cell surface. These findings imply that fibronectin receptors are recirculated to the leading edge of a motile cell by the endocytic cycle, and establish that the processes of endocytosis/exocytosis and cell locomotion are intimately linked.

PubMed Disclaimer

References

    1. Int J Cancer. 1983 Jan 15;31(1):111-7 - PubMed
    1. J Immunol Methods. 1982 Dec 17;55(2):231-42 - PubMed
    1. Annu Rev Biochem. 1983;52:761-99 - PubMed
    1. EMBO J. 1983;2(4):599-603 - PubMed
    1. EMBO J. 1982;1(3):351-5 - PubMed

Substances